Inherited disorders of the IL-12-IFN-γ axis in patients with disseminated BCG infection

Davood Mansouri, Parisa Adimi, Mehdi Mirsaeidi, Nahal Mansouri, Soheila Khalilzadeh, Mohammad R. Masjedi, Parvaneh Adimi, Payam Tabarsi, Mohammad Naderi, Orchidée Filipe-Santos, Guillaume Vogt, Ludovic De Beaucoudrey, Jacinta Bustamante, Ariane Chapgier, Jacqueline Feinberg, Ali A. Velayati, Jean Laurent Casanova

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Disseminated BCG infection is a rare complication of vaccination that occurs in patients with impaired immunity. In recent years, a series of inherited disorders of the IL-12-IFN-γ axis have been described that predispose affected individuals to disseminated disease caused by BCG, environmental Mycobacteria, and non-typhoidal Salmonella. The routine immunological work-up of these patients is normal and the diagnosis requires specific investigation of the IL-12-IFN-γ circuit. We report here the first two such patients originating from and living in Iran. The first child is two years old and suffers from complete IFN-γ receptor 2 deficiency and disseminated BCG infection. He is currently in clinical remission thanks to prolonged multiple antibiotic therapy. The other, a 28-year-old adult, suffers from IL-12p40 deficiency and presented with disseminated BCG infection followed by recurrent episodes of systemic salmonellosis. He is now doing well. A third patient of Iranian descent, living in North America, was reported elsewhere to suffer from IL-12Rβ1 deficiency. These three patients thus indicate that various inherited defects of the IL-12-IFN-γ circuit can be found in Iranian people. In conclusion we recommend to consider the disorders of the IL-12-IFN-γ circuit in all patients with severe BCG infection, disseminated environmental mycobacterial disease, or systemic non-typhoidal salmonellosis, regardless of their ethnic origin and country of residence.

Original languageEnglish (US)
Pages (from-to)753-757
Number of pages5
JournalEuropean Journal of Pediatrics
Volume164
Issue number12
DOIs
StatePublished - Dec 1 2005
Externally publishedYes

Keywords

  • BCG
  • Immunodeficiency
  • Interferon-γ
  • Interleukin-12
  • Salmonella

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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    Mansouri, D., Adimi, P., Mirsaeidi, M., Mansouri, N., Khalilzadeh, S., Masjedi, M. R., Adimi, P., Tabarsi, P., Naderi, M., Filipe-Santos, O., Vogt, G., De Beaucoudrey, L., Bustamante, J., Chapgier, A., Feinberg, J., Velayati, A. A., & Casanova, J. L. (2005). Inherited disorders of the IL-12-IFN-γ axis in patients with disseminated BCG infection. European Journal of Pediatrics, 164(12), 753-757. https://doi.org/10.1007/s00431-005-1689-9