Influenza virus primes mice for pneumonia from Staphylococcus aureus

Amy R. Iverson, Kelli L. Boyd, Julie L. McAuley, Lisa R. Plano, Mark E. Hart, Jonathan A. McCullers

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Superinfections from Staphylococcus aureus following influenza are an increasing concern. We assessed several laboratory and clinical strains in a mouse coinfection model with influenza virus. A methicillin-resistant USA300 clone and several recent clinical strains from patients with necrotizing pneumonia caused high mortality following influenza virus infection in mice. Both viral and bacterial lung titers were enhanced during coinfections compared with single infections. However, differences in titers did not correspond with differences in disease outcomes in a comparison of superinfections from a highly pathogenic strain with those from a poorly pathogenic strain. These strains did differ, however, in expression of Panton-Valentine leukocidin and in the degree of inflammatory lung damage each engendered. The viral cytotoxin PB1-F2 contributed to the negative outcomes. These data suggest that additional study of specific bacterial virulence factors involved in the pathogenesis of inflammation and lung damage during coinfections is needed.

Original languageEnglish
Pages (from-to)880-888
Number of pages9
JournalJournal of Infectious Diseases
Volume203
Issue number6
DOIs
StatePublished - Mar 15 2011

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Staphylococcal Pneumonia
Orthomyxoviridae
Coinfection
Superinfection
Lung
Methicillin Resistance
Cytotoxins
Virulence Factors
Virus Diseases
Human Influenza
Staphylococcus aureus
Pneumonia
Clone Cells
Mortality
Infection

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy

Cite this

Iverson, A. R., Boyd, K. L., McAuley, J. L., Plano, L. R., Hart, M. E., & McCullers, J. A. (2011). Influenza virus primes mice for pneumonia from Staphylococcus aureus. Journal of Infectious Diseases, 203(6), 880-888. https://doi.org/10.1093/infdis/jiq113

Influenza virus primes mice for pneumonia from Staphylococcus aureus. / Iverson, Amy R.; Boyd, Kelli L.; McAuley, Julie L.; Plano, Lisa R.; Hart, Mark E.; McCullers, Jonathan A.

In: Journal of Infectious Diseases, Vol. 203, No. 6, 15.03.2011, p. 880-888.

Research output: Contribution to journalArticle

Iverson, AR, Boyd, KL, McAuley, JL, Plano, LR, Hart, ME & McCullers, JA 2011, 'Influenza virus primes mice for pneumonia from Staphylococcus aureus', Journal of Infectious Diseases, vol. 203, no. 6, pp. 880-888. https://doi.org/10.1093/infdis/jiq113
Iverson AR, Boyd KL, McAuley JL, Plano LR, Hart ME, McCullers JA. Influenza virus primes mice for pneumonia from Staphylococcus aureus. Journal of Infectious Diseases. 2011 Mar 15;203(6):880-888. https://doi.org/10.1093/infdis/jiq113
Iverson, Amy R. ; Boyd, Kelli L. ; McAuley, Julie L. ; Plano, Lisa R. ; Hart, Mark E. ; McCullers, Jonathan A. / Influenza virus primes mice for pneumonia from Staphylococcus aureus. In: Journal of Infectious Diseases. 2011 ; Vol. 203, No. 6. pp. 880-888.
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