Influences of related retroviruses on lymphocyte functions

Narendra Chirmule, Carl Saxinger, Savita Pahwa

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The human immunodeficiency virus (HIV-1) is known to be profoundly immunosuppressive [Spickett and Dalgleish (1988) Clin. Exp. Immunol. 71, 1]. In this communication, we have studied the influences of HIV-1 (BH10), HIV-2 (LAV-2) and STLV-3 on B and T cells from healthy volunteers. B lymphocytes were found to differentiate into immunoglobulin secreting cells in response to stimulation by proteins of HIV-1 and LAV-2, but not by STLV-3. This response was obtained at protein concentrations of 0.05-0.005 μg/ml and was T cell dependent. IgM secretion was induced only by HIV-1 in the EBV-transformed B cell line SKW 6.4. At higher concentrations all three retroviral preparations had inhibitory influences on functions of B as well as T lymphocytes. B cell differentiation was maximally inhibited by HIV-1 and LAV-2 when these proteins were added concurrently to cultures with the polyclonal B cell activators pokeweed mitogen or Epstein-Barr virus. Tetanus antigen-specific T cell lymphoproliferation was inhibited by all retroviral proteins. These findings suggest that related retroviruses differ in their capacity to influence normal immune responses.

Original languageEnglish (US)
Pages (from-to)271-278
Number of pages8
JournalFEMS microbiology letters
Volume47
Issue number5
DOIs
StatePublished - Apr 1989
Externally publishedYes

Keywords

  • HIV-1
  • LAV-2
  • Related retroviruses
  • STLV-3

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Microbiology
  • Immunology
  • Microbiology (medical)

Fingerprint Dive into the research topics of 'Influences of related retroviruses on lymphocyte functions'. Together they form a unique fingerprint.

  • Cite this