Influences of related retroviruses on lymphocyte functions

Narendra Chirmule, Carl Saxinger, Savita G Pahwa

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The human immunodeficiency virus (HIV-1) is known to be profoundly immunosuppressive [Spickett and Dalgleish (1988) Clin. Exp. Immunol. 71, 1]. In this communication, we have studied the influences of HIV-1 (BH10), HIV-2 (LAV-2) and STLV-3 on B and T cells from healthy volunteers. B lymphocytes were found to differentiate into immunoglobulin secreting cells in response to stimulation by proteins of HIV-1 and LAV-2, but not by STLV-3. This response was obtained at protein concentrations of 0.05-0.005 μg/ml and was T cell dependent. IgM secretion was induced only by HIV-1 in the EBV-transformed B cell line SKW 6.4. At higher concentrations all three retroviral preparations had inhibitory influences on functions of B as well as T lymphocytes. B cell differentiation was maximally inhibited by HIV-1 and LAV-2 when these proteins were added concurrently to cultures with the polyclonal B cell activators pokeweed mitogen or Epstein-Barr virus. Tetanus antigen-specific T cell lymphoproliferation was inhibited by all retroviral proteins. These findings suggest that related retroviruses differ in their capacity to influence normal immune responses.

Original languageEnglish
Pages (from-to)271-278
Number of pages8
JournalFEMS Microbiology Letters
Volume47
Issue number5
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

Fingerprint

Retroviridae
HIV-1
HIV-2
Lymphocytes
B-Lymphocytes
Simian T-lymphotropic virus 3
T-Lymphocytes
Human Herpesvirus 4
Proteins
Antibody-Producing Cells
Pokeweed Mitogens
Transformed Cell Line
Tetanus
Immunosuppressive Agents
Immunoglobulin M
Cell Differentiation
Healthy Volunteers
Antigens

Keywords

  • HIV-1
  • LAV-2
  • Related retroviruses
  • STLV-3

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Microbiology
  • Immunology
  • Microbiology (medical)

Cite this

Influences of related retroviruses on lymphocyte functions. / Chirmule, Narendra; Saxinger, Carl; Pahwa, Savita G.

In: FEMS Microbiology Letters, Vol. 47, No. 5, 01.01.1989, p. 271-278.

Research output: Contribution to journalArticle

Chirmule, Narendra ; Saxinger, Carl ; Pahwa, Savita G. / Influences of related retroviruses on lymphocyte functions. In: FEMS Microbiology Letters. 1989 ; Vol. 47, No. 5. pp. 271-278.
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