Influences of Nutrition Supply and Pathways on the Degenerative Patterns in Human Intervertebral Disc

Qiaoqiao Zhu, Xin Gao, Howard Levene, Mark Brown, Weiyong Gu

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

STUDY DESIGN.: Investigation of the effects of the impairment of different nutritional pathways on the intervertebral disc degeneration patterns in terms of spatial distributions of cell density, glycosaminoglycan content, and water content. OBJECTIVE.: To test the hypothesis that impairment of different nutritional pathways would result in different degenerative patterns in human discs. SUMMARY OF BACKGROUND DATA.: Impairment of nutritional pathways has been found to affect cell viability in the disc. However, details on how impairment of different nutritional pathways affects the disc degeneration patterns are unknown. METHODS.: A 3D finite element model was used for this study. This finite element method was based on the cell-activity-coupled mechano-electrochemical theory for cartilaginous tissues. Impairment of the nutritional pathways was simulated by lowering the nutrition level at the disc boundaries. Effects of the impartment of cartilaginous endplate-nucleus pulposus (CEP-NP) pathway only (Case 1), annulus fibrosus (AF) pathway only (Case 2), and both pathways (Case 3) on disc degeneration patterns were studied. RESULTS.: The predicted critical level of nutrition for Case 1, Case 2, and Case 3 were around 30%, 20%, and 50% of the reference values, respectively. Below this critical level, the disc degeneration would occur. Disc degeneration appeared mainly in the NP for Case 1, in the outer AF for Case 2, and in both the NP and inner to middle AF for Case 3. For Cases 1 and 3, the loss of water content was primarily located in the mid-axial plane, which is consistent with the horizontal gray band seen in some T2-weighted MRI images. For the disc geometry used in this study, it was predicted that there existed a High Intensity Zone (for Case 3), as seen in some T2-weighted MRI images. CONCLUSION.: Impairment of different nutrition pathways results in different degenerative patterns.Level of Evidence: N/A

Original languageEnglish (US)
JournalSpine
DOIs
StateAccepted/In press - Dec 8 2015

Fingerprint

Intervertebral Disc Degeneration
Intervertebral Disc
Water
Glycosaminoglycans
Cell Survival
Reference Values
Cell Count
Annulus Fibrosus

ASJC Scopus subject areas

  • Clinical Neurology
  • Orthopedics and Sports Medicine

Cite this

@article{e66faba1a7464ca69b230fb12af89ad7,
title = "Influences of Nutrition Supply and Pathways on the Degenerative Patterns in Human Intervertebral Disc",
abstract = "STUDY DESIGN.: Investigation of the effects of the impairment of different nutritional pathways on the intervertebral disc degeneration patterns in terms of spatial distributions of cell density, glycosaminoglycan content, and water content. OBJECTIVE.: To test the hypothesis that impairment of different nutritional pathways would result in different degenerative patterns in human discs. SUMMARY OF BACKGROUND DATA.: Impairment of nutritional pathways has been found to affect cell viability in the disc. However, details on how impairment of different nutritional pathways affects the disc degeneration patterns are unknown. METHODS.: A 3D finite element model was used for this study. This finite element method was based on the cell-activity-coupled mechano-electrochemical theory for cartilaginous tissues. Impairment of the nutritional pathways was simulated by lowering the nutrition level at the disc boundaries. Effects of the impartment of cartilaginous endplate-nucleus pulposus (CEP-NP) pathway only (Case 1), annulus fibrosus (AF) pathway only (Case 2), and both pathways (Case 3) on disc degeneration patterns were studied. RESULTS.: The predicted critical level of nutrition for Case 1, Case 2, and Case 3 were around 30{\%}, 20{\%}, and 50{\%} of the reference values, respectively. Below this critical level, the disc degeneration would occur. Disc degeneration appeared mainly in the NP for Case 1, in the outer AF for Case 2, and in both the NP and inner to middle AF for Case 3. For Cases 1 and 3, the loss of water content was primarily located in the mid-axial plane, which is consistent with the horizontal gray band seen in some T2-weighted MRI images. For the disc geometry used in this study, it was predicted that there existed a High Intensity Zone (for Case 3), as seen in some T2-weighted MRI images. CONCLUSION.: Impairment of different nutrition pathways results in different degenerative patterns.Level of Evidence: N/A",
author = "Qiaoqiao Zhu and Xin Gao and Howard Levene and Mark Brown and Weiyong Gu",
year = "2015",
month = "12",
day = "8",
doi = "10.1097/BRS.0000000000001292",
language = "English (US)",
journal = "Spine",
issn = "0362-2436",
publisher = "Lippincott Williams and Wilkins",

}

TY - JOUR

T1 - Influences of Nutrition Supply and Pathways on the Degenerative Patterns in Human Intervertebral Disc

AU - Zhu, Qiaoqiao

AU - Gao, Xin

AU - Levene, Howard

AU - Brown, Mark

AU - Gu, Weiyong

PY - 2015/12/8

Y1 - 2015/12/8

N2 - STUDY DESIGN.: Investigation of the effects of the impairment of different nutritional pathways on the intervertebral disc degeneration patterns in terms of spatial distributions of cell density, glycosaminoglycan content, and water content. OBJECTIVE.: To test the hypothesis that impairment of different nutritional pathways would result in different degenerative patterns in human discs. SUMMARY OF BACKGROUND DATA.: Impairment of nutritional pathways has been found to affect cell viability in the disc. However, details on how impairment of different nutritional pathways affects the disc degeneration patterns are unknown. METHODS.: A 3D finite element model was used for this study. This finite element method was based on the cell-activity-coupled mechano-electrochemical theory for cartilaginous tissues. Impairment of the nutritional pathways was simulated by lowering the nutrition level at the disc boundaries. Effects of the impartment of cartilaginous endplate-nucleus pulposus (CEP-NP) pathway only (Case 1), annulus fibrosus (AF) pathway only (Case 2), and both pathways (Case 3) on disc degeneration patterns were studied. RESULTS.: The predicted critical level of nutrition for Case 1, Case 2, and Case 3 were around 30%, 20%, and 50% of the reference values, respectively. Below this critical level, the disc degeneration would occur. Disc degeneration appeared mainly in the NP for Case 1, in the outer AF for Case 2, and in both the NP and inner to middle AF for Case 3. For Cases 1 and 3, the loss of water content was primarily located in the mid-axial plane, which is consistent with the horizontal gray band seen in some T2-weighted MRI images. For the disc geometry used in this study, it was predicted that there existed a High Intensity Zone (for Case 3), as seen in some T2-weighted MRI images. CONCLUSION.: Impairment of different nutrition pathways results in different degenerative patterns.Level of Evidence: N/A

AB - STUDY DESIGN.: Investigation of the effects of the impairment of different nutritional pathways on the intervertebral disc degeneration patterns in terms of spatial distributions of cell density, glycosaminoglycan content, and water content. OBJECTIVE.: To test the hypothesis that impairment of different nutritional pathways would result in different degenerative patterns in human discs. SUMMARY OF BACKGROUND DATA.: Impairment of nutritional pathways has been found to affect cell viability in the disc. However, details on how impairment of different nutritional pathways affects the disc degeneration patterns are unknown. METHODS.: A 3D finite element model was used for this study. This finite element method was based on the cell-activity-coupled mechano-electrochemical theory for cartilaginous tissues. Impairment of the nutritional pathways was simulated by lowering the nutrition level at the disc boundaries. Effects of the impartment of cartilaginous endplate-nucleus pulposus (CEP-NP) pathway only (Case 1), annulus fibrosus (AF) pathway only (Case 2), and both pathways (Case 3) on disc degeneration patterns were studied. RESULTS.: The predicted critical level of nutrition for Case 1, Case 2, and Case 3 were around 30%, 20%, and 50% of the reference values, respectively. Below this critical level, the disc degeneration would occur. Disc degeneration appeared mainly in the NP for Case 1, in the outer AF for Case 2, and in both the NP and inner to middle AF for Case 3. For Cases 1 and 3, the loss of water content was primarily located in the mid-axial plane, which is consistent with the horizontal gray band seen in some T2-weighted MRI images. For the disc geometry used in this study, it was predicted that there existed a High Intensity Zone (for Case 3), as seen in some T2-weighted MRI images. CONCLUSION.: Impairment of different nutrition pathways results in different degenerative patterns.Level of Evidence: N/A

UR - http://www.scopus.com/inward/record.url?scp=84949447261&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84949447261&partnerID=8YFLogxK

U2 - 10.1097/BRS.0000000000001292

DO - 10.1097/BRS.0000000000001292

M3 - Article

C2 - 26650874

AN - SCOPUS:84949447261

JO - Spine

JF - Spine

SN - 0362-2436

ER -