Influence of Vitamin D on Islet Autoimmunity and Beta-Cell Function in Type 1 Diabetes

Marco Infante, Camillo Ricordi, Janine Sanchez, Michael J. Clare-Salzler, Nathalia Padilla, Virginia Fuenmayor, Carmen Chavez, Ana Alvarez, David Baidal, Rodolfo Alejandro, Massimiliano Caprio, Andrea Fabbri

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Type 1 diabetes (T1D) is a chronic autoimmune disease leading to immune-mediated destruction of pancreatic beta cells, resulting in the need for insulin therapy. The incidence of T1D is increasing worldwide, thus prompting researchers to investigate novel immunomodulatory strategies to halt autoimmunity and modify disease progression. T1D is considered as a multifactorial disease, in which genetic predisposition and environmental factors interact to promote the triggering of autoimmune responses against beta cells. Over the last decades, it has become clear that vitamin D exerts anti-inflammatory and immunomodulatory effects, apart from its well-established role in the regulation of calcium homeostasis and bone metabolism. Importantly, the global incidence of vitamin D deficiency is also dramatically increasing and epidemiologic evidence suggests an involvement of vitamin D deficiency in T1D pathogenesis. Polymorphisms in genes critical for vitamin D metabolism have also been shown to modulate the risk of T1D. Moreover, several studies have investigated the role of vitamin D (in different doses and formulations) as a potential adjuvant immunomodulatory therapy in patients with new-onset and established T1D. This review aims to present the current knowledge on the immunomodulatory effects of vitamin D and summarize the clinical interventional studies investigating its use for prevention or treatment of T1D.

Original languageEnglish (US)
JournalNutrients
Volume11
Issue number9
DOIs
StatePublished - Sep 11 2019

Fingerprint

autoimmunity
insulin-dependent diabetes mellitus
vitamin D
Autoimmunity
Type 1 Diabetes Mellitus
Vitamin D
vitamin D deficiency
cells
Vitamin D Deficiency
incidence
bone metabolism
Immunomodulation
autoimmune diseases
Incidence
islets of Langerhans
Insulin-Secreting Cells
genetic disorders
Genetic Predisposition to Disease
disease course
polymorphism

Keywords

  • alfacalcidol
  • autoimmunity
  • calcidiol
  • calcitriol
  • cholecalciferol
  • honeymoon phase
  • immunotherapy
  • T1D
  • type 1 diabetes
  • vitamin D

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

Influence of Vitamin D on Islet Autoimmunity and Beta-Cell Function in Type 1 Diabetes. / Infante, Marco; Ricordi, Camillo; Sanchez, Janine; Clare-Salzler, Michael J.; Padilla, Nathalia; Fuenmayor, Virginia; Chavez, Carmen; Alvarez, Ana; Baidal, David; Alejandro, Rodolfo; Caprio, Massimiliano; Fabbri, Andrea.

In: Nutrients, Vol. 11, No. 9, 11.09.2019.

Research output: Contribution to journalReview article

Infante, M, Ricordi, C, Sanchez, J, Clare-Salzler, MJ, Padilla, N, Fuenmayor, V, Chavez, C, Alvarez, A, Baidal, D, Alejandro, R, Caprio, M & Fabbri, A 2019, 'Influence of Vitamin D on Islet Autoimmunity and Beta-Cell Function in Type 1 Diabetes', Nutrients, vol. 11, no. 9. https://doi.org/10.3390/nu11092185
Infante, Marco ; Ricordi, Camillo ; Sanchez, Janine ; Clare-Salzler, Michael J. ; Padilla, Nathalia ; Fuenmayor, Virginia ; Chavez, Carmen ; Alvarez, Ana ; Baidal, David ; Alejandro, Rodolfo ; Caprio, Massimiliano ; Fabbri, Andrea. / Influence of Vitamin D on Islet Autoimmunity and Beta-Cell Function in Type 1 Diabetes. In: Nutrients. 2019 ; Vol. 11, No. 9.
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