Influence of prenatal cocaine exposure on full-term infant neurobehavioral functioning

Connie E Morrow, Emmalee S Bandstra, James C. Anthony, Audrey Ofir, Lihua Xue, Mary L. Reyes

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

This study investigated infant neurobehavioral functioning during the newborn period in 334 full-term, African American neonates (187 cocaine exposed, 147 non-cocaine exposed) enrolled prospectively at birth, with documentation of drug exposure status through maternal interview and urine and meconium toxicology assays. Infants were assessed using the Brazelton Neonatal Behavioral Assessment Scale (BNBAS) during the newborn period (0-6 postnatal days). Findings from multivariate profile analyses support a consistent, modest effect of prenatal cocaine exposure on neurobehavioral functioning in full-term neonates. All of the BNBAS cluster scores, with the exception of abnormal reflexes, were similarly affected, sharing a common slope (D=-0.14; 95% CI=-0.27, -0.003; P=.046) representing a -0.14 point difference between cocaine-exposed and non-cocaine-exposed infants after controlling for prenatal exposure to alcohol, tobacco, and marijuana (ATM); maternal age, education, employment, primigravida status, and prenatal care visits; and infant sex and postnatal age in days. Fetal growth was also related to neurobehavioral functioning and, in part, mediated the relationship between cocaine exposure and the BNBAS cluster scores. Cocaine exposure during each trimester similarly influenced infant neurobehavioral profiles, with cocaine-associated deficits most pronounced in infants with exposure in all three trimesters. Results from qualitative and quantitative urine and meconium bioassay indicators further substantiated these results. Findings, while significant, represent modest effect sizes in full-term infants.

Original languageEnglish
Pages (from-to)533-544
Number of pages12
JournalNeurotoxicology and Teratology
Volume23
Issue number6
DOIs
StatePublished - Dec 1 2001

Fingerprint

Cocaine
Newborn Infant
Meconium
Urine
Tobacco
Bioassay
Abnormal Reflexes
Cannabis
Prenatal Care
Maternal Age
Fetal Development
Assays
Biological Assay
Documentation
African Americans
Toxicology
Education
Alcohols
Multivariate Analysis
Mothers

Keywords

  • Brazelton Neonatal Behavioral Assessment Scale
  • Cocaine
  • Infant
  • Neurobehavior
  • Prenatal

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Neuroscience(all)
  • Toxicology

Cite this

Influence of prenatal cocaine exposure on full-term infant neurobehavioral functioning. / Morrow, Connie E; Bandstra, Emmalee S; Anthony, James C.; Ofir, Audrey; Xue, Lihua; Reyes, Mary L.

In: Neurotoxicology and Teratology, Vol. 23, No. 6, 01.12.2001, p. 533-544.

Research output: Contribution to journalArticle

Morrow, Connie E ; Bandstra, Emmalee S ; Anthony, James C. ; Ofir, Audrey ; Xue, Lihua ; Reyes, Mary L. / Influence of prenatal cocaine exposure on full-term infant neurobehavioral functioning. In: Neurotoxicology and Teratology. 2001 ; Vol. 23, No. 6. pp. 533-544.
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