Influence of plasma proteins on the onset of hypnotic action of intravenous midazolam

N. J. HALLIDAY; J. W. DUNDEE; P. S. COLLIER; P. G. LOUGHRAN; K. W. HARPER

doi:10.1111/j.1365-2044.1985.tb11001.x

Influence of plasma proteins on the onset of hypnotic action of intravenous midazolam

N. J. HALLIDAY, J. W. DUNDEE, P. S. COLLIER, P. G. LOUGHRAN, K. W. HARPER

Anesthesiology

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The action of midazolam is influenced by serum protein binding as seen in the relationship between the time of onset of action of a fixed dose of the drug and the plasma albumin. Pretreatment with intravenous aspirin produces a decrease in the in vitro binding of midazolam. In vivo this is manifest as an increase in the rapidity of action of the benzodiazepines. Probenecid pretreatment will also cause a decrease in the onset time of midazolam. However, this is not due to altered plasma protein binding of the sedative.

Original language	English (US)
Pages (from-to)	763-766
Number of pages	4
Journal	Anaesthesia
Volume	40
Issue number	8
DOIs	https://doi.org/10.1111/j.1365-2044.1985.tb11001.x
State	Published - Aug 1985

Keywords

Hypnotics, benzodiazepines; midazolam

ASJC Scopus subject areas

Anesthesiology and Pain Medicine

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AU - DUNDEE, J. W.

AU - COLLIER, P. S.

AU - LOUGHRAN, P. G.

AU - HARPER, K. W.

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AB - The action of midazolam is influenced by serum protein binding as seen in the relationship between the time of onset of action of a fixed dose of the drug and the plasma albumin. Pretreatment with intravenous aspirin produces a decrease in the in vitro binding of midazolam. In vivo this is manifest as an increase in the rapidity of action of the benzodiazepines. Probenecid pretreatment will also cause a decrease in the onset time of midazolam. However, this is not due to altered plasma protein binding of the sedative.

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Influence of plasma proteins on the onset of hypnotic action of intravenous midazolam

Abstract

Keywords

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