Influence of plasma proteins on the onset of hypnotic action of intravenous midazolam

N. J. Halliday, J. W. Dundee, P. S. Collier, P. G. Loughran, K. W. Harper

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The action of midazolam is influenced by serum protein binding as seen in the relationship between the time of onset of action of a fixed dose of the drug and the plasma albumin. Pretreatment with intravenous aspirin produces a decrease in the in vitro binding of midazolam. In vivo this is manifest as an increase in the rapidity of action of the benzodiazepines. Probenecid pretreatment will also cause a decrease in the onset time of midazolam. However, this is not due to altered plasma protein binding of the sedative.

Original languageEnglish
Pages (from-to)763-766
Number of pages4
JournalAnaesthesia
Volume40
Issue number8
DOIs
StatePublished - Nov 28 1985
Externally publishedYes

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Midazolam
Hypnotics and Sedatives
Blood Proteins
Protein Binding
Probenecid
Benzodiazepines
Serum Albumin
Aspirin
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Halliday, N. J., Dundee, J. W., Collier, P. S., Loughran, P. G., & Harper, K. W. (1985). Influence of plasma proteins on the onset of hypnotic action of intravenous midazolam. Anaesthesia, 40(8), 763-766. https://doi.org/10.1111/j.1365-2044.1985.tb11001.x

Influence of plasma proteins on the onset of hypnotic action of intravenous midazolam. / Halliday, N. J.; Dundee, J. W.; Collier, P. S.; Loughran, P. G.; Harper, K. W.

In: Anaesthesia, Vol. 40, No. 8, 28.11.1985, p. 763-766.

Research output: Contribution to journalArticle

Halliday, NJ, Dundee, JW, Collier, PS, Loughran, PG & Harper, KW 1985, 'Influence of plasma proteins on the onset of hypnotic action of intravenous midazolam', Anaesthesia, vol. 40, no. 8, pp. 763-766. https://doi.org/10.1111/j.1365-2044.1985.tb11001.x
Halliday, N. J. ; Dundee, J. W. ; Collier, P. S. ; Loughran, P. G. ; Harper, K. W. / Influence of plasma proteins on the onset of hypnotic action of intravenous midazolam. In: Anaesthesia. 1985 ; Vol. 40, No. 8. pp. 763-766.
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