Influence of plasma proteins on the onset of hypnotic action of intravenous midazolam

N. J. HALLIDAY, J. W. DUNDEE, P. S. COLLIER, P. G. LOUGHRAN, K. W. HARPER

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22 Scopus citations

Abstract

The action of midazolam is influenced by serum protein binding as seen in the relationship between the time of onset of action of a fixed dose of the drug and the plasma albumin. Pretreatment with intravenous aspirin produces a decrease in the in vitro binding of midazolam. In vivo this is manifest as an increase in the rapidity of action of the benzodiazepines. Probenecid pretreatment will also cause a decrease in the onset time of midazolam. However, this is not due to altered plasma protein binding of the sedative.

Original languageEnglish (US)
Pages (from-to)763-766
Number of pages4
JournalAnaesthesia
Volume40
Issue number8
DOIs
StatePublished - Aug 1985

Keywords

  • Hypnotics, benzodiazepines; midazolam

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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    HALLIDAY, N. J., DUNDEE, J. W., COLLIER, P. S., LOUGHRAN, P. G., & HARPER, K. W. (1985). Influence of plasma proteins on the onset of hypnotic action of intravenous midazolam. Anaesthesia, 40(8), 763-766. https://doi.org/10.1111/j.1365-2044.1985.tb11001.x