Abstract
The action of midazolam is influenced by serum protein binding as seen in the relationship between the time of onset of action of a fixed dose of the drug and the plasma albumin. Pretreatment with intravenous aspirin produces a decrease in the in vitro binding of midazolam. In vivo this is manifest as an increase in the rapidity of action of the benzodiazepines. Probenecid pretreatment will also cause a decrease in the onset time of midazolam. However, this is not due to altered plasma protein binding of the sedative.
| Original language | English |
|---|---|
| Pages (from-to) | 763-766 |
| Number of pages | 4 |
| Journal | Anaesthesia |
| Volume | 40 |
| Issue number | 8 |
| DOIs | |
| State | Published - Nov 28 1985 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Anesthesiology and Pain Medicine
Cite this
Influence of plasma proteins on the onset of hypnotic action of intravenous midazolam. / Halliday, N. J.; Dundee, J. W.; Collier, P. S.; Loughran, P. G.; Harper, K. W.
In: Anaesthesia, Vol. 40, No. 8, 28.11.1985, p. 763-766.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Influence of plasma proteins on the onset of hypnotic action of intravenous midazolam
AU - Halliday, N. J.
AU - Dundee, J. W.
AU - Collier, P. S.
AU - Loughran, P. G.
AU - Harper, K. W.
PY - 1985/11/28
Y1 - 1985/11/28
N2 - The action of midazolam is influenced by serum protein binding as seen in the relationship between the time of onset of action of a fixed dose of the drug and the plasma albumin. Pretreatment with intravenous aspirin produces a decrease in the in vitro binding of midazolam. In vivo this is manifest as an increase in the rapidity of action of the benzodiazepines. Probenecid pretreatment will also cause a decrease in the onset time of midazolam. However, this is not due to altered plasma protein binding of the sedative.
AB - The action of midazolam is influenced by serum protein binding as seen in the relationship between the time of onset of action of a fixed dose of the drug and the plasma albumin. Pretreatment with intravenous aspirin produces a decrease in the in vitro binding of midazolam. In vivo this is manifest as an increase in the rapidity of action of the benzodiazepines. Probenecid pretreatment will also cause a decrease in the onset time of midazolam. However, this is not due to altered plasma protein binding of the sedative.
UR - http://www.scopus.com/inward/record.url?scp=0021933965&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021933965&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2044.1985.tb11001.x
DO - 10.1111/j.1365-2044.1985.tb11001.x
M3 - Article
C2 - 2931035
AN - SCOPUS:0021933965
VL - 40
SP - 763
EP - 766
JO - Anaesthesia
JF - Anaesthesia
SN - 0003-2409
IS - 8
ER -