Abstract
The action of midazolam is influenced by serum protein binding as seen in the relationship between the time of onset of action of a fixed dose of the drug and the plasma albumin. Pretreatment with intravenous aspirin produces a decrease in the in vitro binding of midazolam. In vivo this is manifest as an increase in the rapidity of action of the benzodiazepines. Probenecid pretreatment will also cause a decrease in the onset time of midazolam. However, this is not due to altered plasma protein binding of the sedative.
Original language | English (US) |
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Pages (from-to) | 763-766 |
Number of pages | 4 |
Journal | Anaesthesia |
Volume | 40 |
Issue number | 8 |
DOIs | |
State | Published - Aug 1985 |
Keywords
- Hypnotics, benzodiazepines; midazolam
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine