EFFORTS have been made to incorporate "cholinergic systems" into artificial lipid membranes1-5. In all cases, material was obtained from animal tissues and incorporated into artificial systems, cholinergic drugs were added to the bathing solutions and different "permeability changes" were described. The available information on the interactions between pure lipid membrane and cholinergic agents is, however, scarce 6 and to establish the role of proteins and lipids in the reported findings is difficult. We report here results showing that a negatively charged lipid induces "cholinergic reactivity" in artificial lipid membranes which can be prevented by d-tubocurarine.
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