Influence of LVAD cannula outflow tract location on hemodynamics in the ascending aorta: A patient-specific computational fluid dynamics approach

Christof Karmonik, Sasan Partovi, Matthias Loebe, Bastian Schmack, Ali Ghodsizad, Mark R. Robbin, George P. Noon, Klaus Kallenbach, Matthias Karck, Mark G. Davies, Alan B. Lumsden, Arjang Ruhparwar

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

To develop a better understanding of the hemodynamic alterations in the ascending aorta, induced by variation of the cannula outflow position of the left ventricular assist device (LVAD) device based on patient-specific geometries, transient computational fluid dynamics (CFD) simulations using the realizable k-εturbulent model were conducted for two of the most common LVAD outflow geometries. Thoracic aortic flow patterns, pressures, wall shear stresses (WSSs), turbulent dissipation, and energy were quantified in the ascending aorta at the location of the cannula outflow. Streamlines for the lateral geometry showed a large region of disturbed flow surrounding the LVAD outflow with an impingement zone at the contralateral wall exhibiting increased WSSs and pressures. Flow disturbance was reduced for the anterior geometries with clearly reduced pressures and WSSs. Turbulent dissipation was higher for the lateral geometry and turbulent energy was lower. Variation in the position of the cannula outflow clearly affects hemodynamics in the ascending aorta favoring an anterior geometry for a more ordered flow pattern. The new patient-specific approach used in this study for LVAD patients emphasizes the potential use of CFD as a truly translational technique.

Original languageEnglish (US)
Pages (from-to)562-567
Number of pages6
JournalASAIO Journal
Volume58
Issue number6
DOIs
StatePublished - Nov 1 2012
Externally publishedYes

Keywords

  • ascending aorta
  • computational fluid dynamics
  • left ventricular assist device

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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    Karmonik, C., Partovi, S., Loebe, M., Schmack, B., Ghodsizad, A., Robbin, M. R., Noon, G. P., Kallenbach, K., Karck, M., Davies, M. G., Lumsden, A. B., & Ruhparwar, A. (2012). Influence of LVAD cannula outflow tract location on hemodynamics in the ascending aorta: A patient-specific computational fluid dynamics approach. ASAIO Journal, 58(6), 562-567. https://doi.org/10.1097/MAT.0b013e31826d6232