Influence of insulin status on extra-mitochondrial oxygen metabolism in the rat

J. G. Satav, K. R. Dave, S. S. Katyare

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

The effects of alloxan diabetes and subsequent treatment with insulin on extra-mitochondrial oxygen metabolism in terms of D-amino acid oxidase (DAAO), xanthine oxidase and catalase were examined. The DAAO activity in the liver with Dalanine and D-serine decreased by 33-62% in the diabetic group while the decrease in the kidneys was 61-74%. Insulin treatment resulted in overstimulation of DAAO activity in the liver but not in the kidneys. Tissue glycogen content was lowered in the diabetic animals but was restored by insulin treatment. Tissue glycogen content and DAAO activity showed an inverse relationship. The xanthine oxidase activity in the two tissues decreased from 40-55%; the catalase activity decreased from 34-54%. Insulin treatment was unable to restore the xanthine oxidase and catalase activities in both the tissues.

Original languageEnglish (US)
Pages (from-to)57-61
Number of pages5
JournalHormone and Metabolic Research
Volume32
Issue number2
DOIs
StatePublished - Jan 1 2000

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Keywords

  • Catalase
  • DAAO
  • Diabetes
  • Extra Mitochondrial Oxygen Metabolism
  • Xanthine Oxidase

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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