Influence of insulin status on extra-mitochondrial oxygen metabolism in the rat

J. G. Satav, Kunjan R Dave, S. S. Katyare

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The effects of alloxan diabetes and subsequent treatment with insulin on extra-mitochondrial oxygen metabolism in terms of D-amino acid oxidase (DAAO), xanthine oxidase and catalase were examined. The DAAO activity in the liver with Dalanine and D-serine decreased by 33-62% in the diabetic group while the decrease in the kidneys was 61-74%. Insulin treatment resulted in overstimulation of DAAO activity in the liver but not in the kidneys. Tissue glycogen content was lowered in the diabetic animals but was restored by insulin treatment. Tissue glycogen content and DAAO activity showed an inverse relationship. The xanthine oxidase activity in the two tissues decreased from 40-55%; the catalase activity decreased from 34-54%. Insulin treatment was unable to restore the xanthine oxidase and catalase activities in both the tissues.

Original languageEnglish
Pages (from-to)57-61
Number of pages5
JournalHormone and Metabolic Research
Volume32
Issue number2
StatePublished - Mar 22 2000
Externally publishedYes

Fingerprint

D-Amino-Acid Oxidase
Metabolism
Rats
Xanthine Oxidase
Catalase
Insulin
Tissue
Oxygen
Glycogen
Liver
Kidney
Alloxan
Experimental Diabetes Mellitus
Medical problems
Serine
Animals

Keywords

  • Catalase
  • DAAO
  • Diabetes
  • Extra Mitochondrial Oxygen Metabolism
  • Xanthine Oxidase

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Influence of insulin status on extra-mitochondrial oxygen metabolism in the rat. / Satav, J. G.; Dave, Kunjan R; Katyare, S. S.

In: Hormone and Metabolic Research, Vol. 32, No. 2, 22.03.2000, p. 57-61.

Research output: Contribution to journalArticle

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