Influence of excess dietary cholesterol on thyroid gland function of the male rat

M. T. Nunes, A. C. Bianco, C. R. Douglas

Research output: Contribution to journalArticle

Abstract

In young male rats receiving a cholesterol-enriched diet (1g%) and a normal supply of iodine (50 μg%) during 30 days, there is an enhanced iodine uptake by the thyroid gland (0.40%) in relation to control (0.26%), in conjunction with an augmented secretion of thyroid hormones, conversion index PB131I/131I (0.34 to 0.28), PB131I (0.25% to 0.15%) and total T3 plasma level (98.13 ng/100 ml to 71.83 ng/100 ml), while total T4 plasma level remains unchanged. TSH plasma concentration is also elevated (8.32 μU/ml to 7.57 μU/ml). The results suggest that in conditions of dietary cholesterol excess there would be a higher capacity of the thyroid gland to use iodine in order to synthesize more hormones. This effect perhaps would be secondary to an exaggerated secretion or release of TSH from the pituitary gland.

Original languageEnglish (US)
Pages (from-to)1122-1123
Number of pages2
JournalIRCS Medical Science
Volume9
Issue number12
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Nunes, M. T., Bianco, A. C., & Douglas, C. R. (1981). Influence of excess dietary cholesterol on thyroid gland function of the male rat. IRCS Medical Science, 9(12), 1122-1123.