Influence of breast cancer on thymic function in mice

Diana M Lopez, Vijaya Charyulu, Rebecca D Adkins

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The thymus is the major site of T cell maturation; extensive proliferation, differentiation, and apoptosis occur in this organ. During mammary tumorigenesis, there is a profound involution of the thymus associated with a severe depletion of the most abundant subset of thymocytes, CD4 +8+ immature cells. Experiments to investigate the mechanism of loss of the CD4+8+ population indicated that there was no increase in the systemic levels of glucocorticoids, no loss of bone marrow precursors, and no decrease in precursor seeding of the thymus. Likewise, no enhanced emigration of thymocytes from the thymus to the periphery was observed in tumor-bearing mice. A slight increase in apoptosis was found in tumor bearers' thymi, but there was no apparent decrease in the proliferation of early thymic precursors CD4-8- cells. Importantly, severely altered levels of subpopulations of the CD4-8- precursors, consistent with an arrest in differentiation at an early stage of development, were detected. Moreover, thymic stromal cell function appeared to become impaired during tumorigenesis, possibly due to the action of tumor-derived factors. Thus, downregulation of cell-mediated immune functions occurring at late stages of the disease may be causally related to the thymic involution occurring during mammary tumorigenesis.

Original languageEnglish
Pages (from-to)191-199
Number of pages9
JournalJournal of Mammary Gland Biology and Neoplasia
Volume7
Issue number2
DOIs
StatePublished - Apr 1 2002

Fingerprint

Thymus Gland
Breast Neoplasms
Carcinogenesis
Thymocytes
Breast
Apoptosis
Thymus Neoplasms
Emigration and Immigration
Stromal Cells
Glucocorticoids
Neoplasms
Down-Regulation
Bone Marrow
T-Lymphocytes
Population

Keywords

  • Impaired cell-mediated immunity
  • Mammary tumors
  • T cell
  • Thymus atrophy

ASJC Scopus subject areas

  • Cancer Research

Cite this

Influence of breast cancer on thymic function in mice. / Lopez, Diana M; Charyulu, Vijaya; Adkins, Rebecca D.

In: Journal of Mammary Gland Biology and Neoplasia, Vol. 7, No. 2, 01.04.2002, p. 191-199.

Research output: Contribution to journalArticle

Lopez, Diana M ; Charyulu, Vijaya ; Adkins, Rebecca D. / Influence of breast cancer on thymic function in mice. In: Journal of Mammary Gland Biology and Neoplasia. 2002 ; Vol. 7, No. 2. pp. 191-199.
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