Influence of antioxidant enzymes in reduction of optic disc edema in experimental optic neuritis

John Guy, E. Ann Ellis, G. M. Hope, Narsing A. Rao

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Acute experimental allergic optic neuritis was induced in 18 adult strain-13 guinea pigs. The animals were divided into three groups. The first group of six animals received intraperitoneal injections of saline, the second group received superoxide dismutase (SOD), and the third group received catalase, given daily, starting 1 week after encephalogenic myelin sensitization. Morphometric analysis of longitudinal histopathologic sections of the optic nerve head revealed that the animals treated with the antioxidant enzyme catalase had a statistically significant reduction of optic disc edema when compared to the saline-treated group. Although animals treated with SOD had less optic disc swelling than the saline-treated controls, the differences were not statistically significant. These results indicate that detoxification of hydrogen peroxide, released by invading inflammatory cells, can reduce the severity of axonal swelling within the optic nerve head.

Original languageEnglish (US)
Pages (from-to)349-357
Number of pages9
JournalJournal of Free Radicals in Biology and Medicine
Volume2
Issue number5-6
DOIs
StatePublished - 1986
Externally publishedYes

Keywords

  • Antioxidants
  • Catalase
  • Experimental allergic encephalomyelitis
  • Optic neuritis
  • Oxygen radical scavengers
  • Superoxide dismutase

ASJC Scopus subject areas

  • Biochemistry

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