Inflammatory T helper 17 cells promote depression-like behavior in mice

Eleonore Beurel, Laurie E. Harrington, Richard S Jope

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Background: Recognition of substantial immune-neural interactions is revising dogmas about their insular actions and revealing that immune-neural interactions can substantially impact central nervous system functions. The inflammatory cytokine interleukin-6 promotes susceptibility to depression and drives production of inflammatory T helper 17 (Th17) T cells, raising the hypothesis that in mouse models, Th17 cells promote susceptibility to depression-like behaviors. Methods: Behavioral characteristics were measured in male mice administered Th17 cells, CD4+ cells, or vehicle and in retinoid-related orphan receptor-γT (RORγT)+/GFP mice or male mice treated with RORγT inhibitor or anti-interleukin-17A antibodies. Results: Mouse brain Th17 cells were elevated by learned helplessness and chronic restraint stress, two common depression-like models. Th17 cell administration promoted learned helplessness in 89% of mice in a paradigm where no vehicle-treated mice developed learned helplessness, and impaired novelty suppressed feeding and social interaction behaviors. Mice deficient in the RORγT transcription factor necessary for Th17 cell production exhibited resistance to learned helplessness, identifying modulation of RORγT as a potential intervention. Treatment with the RORγT inhibitor SR1001, or anti-interleukin-17A antibodies to abrogate Th17 cell function, reduced Th17-dependent learned helplessness. Conclusions: These findings indicate that Th17 cells are increased in the brain during depression-like states, promote depression-like behaviors in mice, and specifically inhibiting the production or function of Th17 cells reduces vulnerability to depression-like behavior, suggesting antidepressant effects may be attained by targeting Th17 cells.

Original languageEnglish
Pages (from-to)622-630
Number of pages9
JournalBiological Psychiatry
Volume73
Issue number7
DOIs
StatePublished - Apr 1 2013

Fingerprint

Th17 Cells
Learned Helplessness
Depression
Interleukin-17
Antibodies
Retinoids
Brain
Interpersonal Relations
Antidepressive Agents
Interleukin-6
Transcription Factors
Central Nervous System
Cytokines

Keywords

  • Antidepressant
  • depression
  • learned helplessness
  • neural-immune interactions
  • RORγT
  • Th17 cells

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Inflammatory T helper 17 cells promote depression-like behavior in mice. / Beurel, Eleonore; Harrington, Laurie E.; Jope, Richard S.

In: Biological Psychiatry, Vol. 73, No. 7, 01.04.2013, p. 622-630.

Research output: Contribution to journalArticle

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