Inflammatory fibroid polyp of the small intestine

Ultrastructural and immunohistochemical observations

Saul Suster, Morton J. Robinson, Arkadi M. Rywlin

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The ultrastructural and immunohistochemical features of a primary tumor of the ileum showing the classic histologic features of an inflammatory fibroid polyp (IFP) of the gastrointestinal tract are presented. Ultrastructurally the proliferating cells showed a combination of fibroblastic and histio cytic features, with abundant rough endoplasmic reticulum and active production of collagen in many of the cells and long, dendritic cytoplasmic projections with large cytoplasmic vacuoles containing remnants of phagocytosed cellular debris in others. Immunohistochemical studies showed strong cytoplasmic positivity in the proliferating cells with vi mentin antibodies and scattered positivity with muramidase. Additional findings include the ultra structural demonstration of oligocilia and occasional primitive intercellular junctions. The findings in this case suggest that IFP may represent a proliferation of primitive submucosal stromal cells exhibiting incomplete fibrohistiocytic differentiation.

Original languageEnglish
Pages (from-to)109-119
Number of pages11
JournalUltrastructural Pathology
Volume14
Issue number2
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

Fingerprint

intestines
Leiomyoma
Polyps
Collagen
Debris
Antibodies
Small Intestine
Tumors
Demonstrations
Intercellular Junctions
Rough Endoplasmic Reticulum
Muramidase
Stromal Cells
Vacuoles
Ileum
Phagocytosis
Dendritic Cells
Gastrointestinal Tract
endoplasmic reticulum
collagens

Keywords

  • Benign fibrohistiocytic tumors
  • Immunohisto-chemistry
  • Inflammatory fibroid polyp
  • Oligocilia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Structural Biology
  • Instrumentation

Cite this

Inflammatory fibroid polyp of the small intestine : Ultrastructural and immunohistochemical observations. / Suster, Saul; Robinson, Morton J.; Rywlin, Arkadi M.

In: Ultrastructural Pathology, Vol. 14, No. 2, 01.01.1990, p. 109-119.

Research output: Contribution to journalArticle

Suster, Saul ; Robinson, Morton J. ; Rywlin, Arkadi M. / Inflammatory fibroid polyp of the small intestine : Ultrastructural and immunohistochemical observations. In: Ultrastructural Pathology. 1990 ; Vol. 14, No. 2. pp. 109-119.
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