Inflammatory cytokines during liver transplantation: Prospective randomized trial comparing conventional and piggyback techniques

Carlos Eduardo Sandoli Baía, Edson Abdala, Paulo Massarollo, Thiago Beduschi, Thomson Marques Palma, Sergio Mies

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Background/Aims: Cytokines have a significant role in the response to injury following liver transplantation, but the origin and course of such molecules are not completely known. The aim of this study was to evaluate the production and liver metabolism of the inflammatory cytokines interleukin (IL)-1β, IL-6, IL-8, interferon (IFN)-γ and tumor necrosis factor (TNF)-α in orthotopic liver transplantation (OLT), comparing the conventional and the piggyback methods. Methodology: We performed a study of 30 patients who underwent elective OLT and were randomized for the conventional or piggyback techniques at the beginning of the operation. The amount of cytokines and their hepatic metabolism were calculated based on plasma concentrations and vascular blood flow at 2, 5, 10, 15, 30, 60, 90, and 120 minutes after revascularization. Results: The amount of IL-1β in portal blood was higher in patients who underwent surgery using the conventional technique (estimate interest = 63,783.9 ± 16,586.1 pg/min, versus 11,979.6 ± 16,585.7 pg/min in the piggyback group, p=0.035). There were no significant differences between the two operative's methods for IL-6, IL-8, IFN-γ and TNF-α production. The hepatic metabolism of cytokines was not different between groups. Although all the curves showed higher amounts of cytokines with the conventional technique, these were not statistically significant. Conclusion: The study shows the similarity between the two techniques concerning the stimuli for the production of inflammatory molecules.

Original languageEnglish (US)
Pages (from-to)1445-1451
Number of pages7
Issue number94-95
StatePublished - Jan 1 2009
Externally publishedYes


  • Hemodynamic processes
  • Liver circulation
  • Metabolism
  • Splanchnic circulation
  • Surgical procedures

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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