Inflammatory biomarkers of vascular risk as correlates of leukoariosis

Clinton B Wright, Yeseon Moon, Myunghee C. Paik, Truman R. Brown, Leroy Rabbani, Mitsuhiro Yoshita, Charles Decarli, Ralph L Sacco, Mitchell S V Elkind

Research output: Contribution to journalArticle

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Abstract

BACKGROUND AND PURPOSE-: Inflammatory biomarkers, including lipoprotein-associated phospholipase A2 (Lp-PLA2), myeloperoxidase (MPO), and high-sensitivity C-reactive protein (hsCRP) are associated with ischemic stroke risk. White matter hyperintensities (WMH) seen on brain MRI scans are associated with vascular risk factors and an increased risk of incident stroke, but their relation to inflammatory biomarkers is unclear. METHODS-: The Northern Manhattan Study includes a stroke-free community-based sample of Hispanic, black, and white participants with quantitative measurement of WMH volume (WMHV) and inflammatory biomarkers. We measured the association between Lp-PLA2, MPO, and hsCRP levels, and log-transformed WMHV after adjusting for sociodemographic and vascular risk factors. RESULTS-: The hsCRP (median, 2.42 mg/L; IQR, 1.04, 5.19), Lp-PLA2 (median, 220.97 ng/mL; IQR, 185.77, 268.05), and MPO (median, 15.14 ng/mL; IQR, 12.32, 19.69) levels were available in 527 The Northern Manhattan Study participants with WMHV data but no subclinical infarcts. Those with hsCRP in the upper quartile (Q4 >4.92 mg/L or >3 mg/L), Lp-PLA2 in Q4 (≤264.9 ng/mL), or MPO levels in Q3 (15.04-19.39 ng/mL) or Q4 (>19.39 ng/mL) each had greater WMHV, adjusting for sociodemographic and vascular risk factors. Adjusting for all biomarkers simultaneously, WMHV was 1.3-fold greater for Lp-PLA2 levels in Q4 compared to Q1 (β=0.28; P =0.008) and 1.25-fold greater for MPO levels above the median compared to below (β=0.22; P =0.02), but hsCRP was not associated with WMHV. CONCLUSIONS-: Relative elevations of the inflammatory markers Lp-PLA2 and MPO were associated with a greater burden of WMH independent of hsCRP.

Original languageEnglish
Pages (from-to)3466-3471
Number of pages6
JournalStroke
Volume40
Issue number11
DOIs
StatePublished - Nov 1 2009

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1-Alkyl-2-acetylglycerophosphocholine Esterase
C-Reactive Protein
Peroxidase
Blood Vessels
Biomarkers
Stroke
Hispanic Americans
Magnetic Resonance Imaging
Brain

Keywords

  • C-reactive protein
  • Leukoariosis
  • Lipoprotein-associated phospholipase A2
  • Myeloperoxidase
  • White matter disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing

Cite this

Wright, C. B., Moon, Y., Paik, M. C., Brown, T. R., Rabbani, L., Yoshita, M., ... Elkind, M. S. V. (2009). Inflammatory biomarkers of vascular risk as correlates of leukoariosis. Stroke, 40(11), 3466-3471. https://doi.org/10.1161/STROKEAHA.109.559567

Inflammatory biomarkers of vascular risk as correlates of leukoariosis. / Wright, Clinton B; Moon, Yeseon; Paik, Myunghee C.; Brown, Truman R.; Rabbani, Leroy; Yoshita, Mitsuhiro; Decarli, Charles; Sacco, Ralph L; Elkind, Mitchell S V.

In: Stroke, Vol. 40, No. 11, 01.11.2009, p. 3466-3471.

Research output: Contribution to journalArticle

Wright, CB, Moon, Y, Paik, MC, Brown, TR, Rabbani, L, Yoshita, M, Decarli, C, Sacco, RL & Elkind, MSV 2009, 'Inflammatory biomarkers of vascular risk as correlates of leukoariosis', Stroke, vol. 40, no. 11, pp. 3466-3471. https://doi.org/10.1161/STROKEAHA.109.559567
Wright CB, Moon Y, Paik MC, Brown TR, Rabbani L, Yoshita M et al. Inflammatory biomarkers of vascular risk as correlates of leukoariosis. Stroke. 2009 Nov 1;40(11):3466-3471. https://doi.org/10.1161/STROKEAHA.109.559567
Wright, Clinton B ; Moon, Yeseon ; Paik, Myunghee C. ; Brown, Truman R. ; Rabbani, Leroy ; Yoshita, Mitsuhiro ; Decarli, Charles ; Sacco, Ralph L ; Elkind, Mitchell S V. / Inflammatory biomarkers of vascular risk as correlates of leukoariosis. In: Stroke. 2009 ; Vol. 40, No. 11. pp. 3466-3471.
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abstract = "BACKGROUND AND PURPOSE-: Inflammatory biomarkers, including lipoprotein-associated phospholipase A2 (Lp-PLA2), myeloperoxidase (MPO), and high-sensitivity C-reactive protein (hsCRP) are associated with ischemic stroke risk. White matter hyperintensities (WMH) seen on brain MRI scans are associated with vascular risk factors and an increased risk of incident stroke, but their relation to inflammatory biomarkers is unclear. METHODS-: The Northern Manhattan Study includes a stroke-free community-based sample of Hispanic, black, and white participants with quantitative measurement of WMH volume (WMHV) and inflammatory biomarkers. We measured the association between Lp-PLA2, MPO, and hsCRP levels, and log-transformed WMHV after adjusting for sociodemographic and vascular risk factors. RESULTS-: The hsCRP (median, 2.42 mg/L; IQR, 1.04, 5.19), Lp-PLA2 (median, 220.97 ng/mL; IQR, 185.77, 268.05), and MPO (median, 15.14 ng/mL; IQR, 12.32, 19.69) levels were available in 527 The Northern Manhattan Study participants with WMHV data but no subclinical infarcts. Those with hsCRP in the upper quartile (Q4 >4.92 mg/L or >3 mg/L), Lp-PLA2 in Q4 (≤264.9 ng/mL), or MPO levels in Q3 (15.04-19.39 ng/mL) or Q4 (>19.39 ng/mL) each had greater WMHV, adjusting for sociodemographic and vascular risk factors. Adjusting for all biomarkers simultaneously, WMHV was 1.3-fold greater for Lp-PLA2 levels in Q4 compared to Q1 (β=0.28; P =0.008) and 1.25-fold greater for MPO levels above the median compared to below (β=0.22; P =0.02), but hsCRP was not associated with WMHV. CONCLUSIONS-: Relative elevations of the inflammatory markers Lp-PLA2 and MPO were associated with a greater burden of WMH independent of hsCRP.",
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AU - Moon, Yeseon

AU - Paik, Myunghee C.

AU - Brown, Truman R.

AU - Rabbani, Leroy

AU - Yoshita, Mitsuhiro

AU - Decarli, Charles

AU - Sacco, Ralph L

AU - Elkind, Mitchell S V

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N2 - BACKGROUND AND PURPOSE-: Inflammatory biomarkers, including lipoprotein-associated phospholipase A2 (Lp-PLA2), myeloperoxidase (MPO), and high-sensitivity C-reactive protein (hsCRP) are associated with ischemic stroke risk. White matter hyperintensities (WMH) seen on brain MRI scans are associated with vascular risk factors and an increased risk of incident stroke, but their relation to inflammatory biomarkers is unclear. METHODS-: The Northern Manhattan Study includes a stroke-free community-based sample of Hispanic, black, and white participants with quantitative measurement of WMH volume (WMHV) and inflammatory biomarkers. We measured the association between Lp-PLA2, MPO, and hsCRP levels, and log-transformed WMHV after adjusting for sociodemographic and vascular risk factors. RESULTS-: The hsCRP (median, 2.42 mg/L; IQR, 1.04, 5.19), Lp-PLA2 (median, 220.97 ng/mL; IQR, 185.77, 268.05), and MPO (median, 15.14 ng/mL; IQR, 12.32, 19.69) levels were available in 527 The Northern Manhattan Study participants with WMHV data but no subclinical infarcts. Those with hsCRP in the upper quartile (Q4 >4.92 mg/L or >3 mg/L), Lp-PLA2 in Q4 (≤264.9 ng/mL), or MPO levels in Q3 (15.04-19.39 ng/mL) or Q4 (>19.39 ng/mL) each had greater WMHV, adjusting for sociodemographic and vascular risk factors. Adjusting for all biomarkers simultaneously, WMHV was 1.3-fold greater for Lp-PLA2 levels in Q4 compared to Q1 (β=0.28; P =0.008) and 1.25-fold greater for MPO levels above the median compared to below (β=0.22; P =0.02), but hsCRP was not associated with WMHV. CONCLUSIONS-: Relative elevations of the inflammatory markers Lp-PLA2 and MPO were associated with a greater burden of WMH independent of hsCRP.

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KW - C-reactive protein

KW - Leukoariosis

KW - Lipoprotein-associated phospholipase A2

KW - Myeloperoxidase

KW - White matter disease

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