Inflammation and mood disorders: Proinflammatory cytokines and the pathogenesis of depression

M. Beatriz Currier, Charles B. Nemeroff

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Increasing evidence suggests that activation of the innate immune system may play a seminal role in the pathophysiology of depression. Several lines of evidence support the association of inflammation and depression. Peripheral administration of cytokines, such as interferon-alpha, can induce many of the symptoms of the depressive syndrome. In addition, medically healthy patients with major depression exhibit elevated plasma levels of proinflammatory cytokines. Moreover, cytokines produce effects on a variety of neurobiological substrates previously implicated in the pathogenesis of depression. Thus, proinflammatory cytokines alter neuroendocrine function, several neurotransmitter systems including dopamine and glutamate, neural plasticity, and neuronal activity in limbic regions. The burgeoning evidence that depression is an inflammatory disease is reviewed.

Original languageEnglish (US)
Pages (from-to)212-220
Number of pages9
JournalAnti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry
Volume9
Issue number3
StatePublished - Oct 29 2010

Keywords

  • Cytokines
  • Depression
  • Hypothalamic-pituitary-adrenal axis
  • Inflammation
  • Monoamine neurotransmitters

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology

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