Inflammation and colorectal cancer

Rishu Dheer, Julie M. Davies, Maria T Abreu

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Chronic intestinal Inflammation occurs in response to environmental factors, infection and genetics; and plays a critical role in initiation, promotion, progression and metastasis of colon cancer. Colitis associated colon cancer (CAC) is a classic example of multifactorial, multi-step colorectal cancer associated with inflammatory bowel diseases. In recent years, the generation of animal models of CAC and recognition of the importance of the gut microbiota, altered immune system, and other environmental factors in CAC, has expanded the basic understanding of inflammation associated colon cancer. In this chapter, we discuss the cellular alterations and mechanisms by which inflammation contributes towards the development of colon cancer using CAC as a model system. We have also explored some of the promising strategies for preventing progression of inflammation to colon cancer. The emerging role of dietary factors, obesity and gut microbiota in colon cancer is also reviewed.

Original languageEnglish (US)
Title of host publicationIntestinal Tumorigenesis: Mechanisms of Development & Progression
PublisherSpringer International Publishing
Pages211-256
Number of pages46
ISBN (Print)9783319199863, 9783319199856
DOIs
StatePublished - Sep 19 2015

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Keywords

  • Chemoprevention
  • Colitis associated colon cancer
  • Cytokines
  • Diet
  • Inflammatory bowel disease
  • Innate immunity
  • Microbiota
  • Molecular pathways
  • Obesity

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Dheer, R., Davies, J. M., & Abreu, M. T. (2015). Inflammation and colorectal cancer. In Intestinal Tumorigenesis: Mechanisms of Development & Progression (pp. 211-256). Springer International Publishing. https://doi.org/10.1007/978-3-319-19986-3_8