Inflammasome proteins as biomarkers of injury and disease

Juan Pablo P de Rivero Vaccari, Juan Carlos de Rivero Vaccari

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The inflammasome is a multi-protein complex of the innate immune response that activates caspase-1 after infections, tissue injury, or disease. Once active caspase-1 cleaves the pro-inflammatory cytokines pro-IL-1β and pro-IL-18 into their respective mature forms, IL-1β and IL-18. Inflammasome proteins such as caspase-1, NOD-like receptor protein-1 (NLRP1), NLRP3, or apoptosisassociated speck-like protein containing a CARD (ASC) can be used as biomarkers of tissue injury and disease. For instance, higher levels of inflammasome proteins are present in the cerebrospinal fluid of patients with traumatic brain injury who present poor outcomes after trauma. Hence, the inflammasome after brain injury can be used as a tool to prognosticate outcomes after brain trauma. Similarly, in rodent models of multiple sclerosis, animals that do not respond to the classic interferon (IFN)-β treatment do not present an NLRP3 inflammasomedependent disease. Thus, the inflammasome in multiple sclerosis can be used as a prognostic tool to identify responders to IFN-β treatment. In the same manner, patients taking finasteride for male pattern baldness who do not respond to treatment correlate with higher levels of caspase-1 in hair follicles. Moreover, the inflammasome can also be used as a biomarker of disease progression in diabetes and atherosclerosis, as well as a biomarker of tissue injury in inflammatory bowel disease and semen quality in patients with male infertility after spinal cord injury. Therefore, the inflammasome, a receptor of the innate immune response, is a useful biomarker in a variety of diseases and tissue injury.

Original languageEnglish (US)
Title of host publicationGeneral Methods in Biomarker Research and their Applications
PublisherSpringer Netherlands
Pages1207-1228
Number of pages22
ISBN (Print)9789400776968, 9789400776951
DOIs
StatePublished - Jan 1 2015

Fingerprint

Inflammasomes
Biomarkers
Caspase 1
Wounds and Injuries
Proteins
Interleukin-18
Interleukin-1
Innate Immunity
Interferons
Multiple Sclerosis
Finasteride
Semen Analysis
Hair Follicle
Male Infertility
Alopecia
Spinal Cord Injuries
Inflammatory Bowel Diseases
Brain Injuries
Cerebrospinal Fluid
Disease Progression

Keywords

  • ASC
  • Caspase-1
  • Cytokines
  • Inflammasome
  • Interleukin-1
  • NALP
  • NLRP

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

de Rivero Vaccari, J. P. P., & de Rivero Vaccari, J. C. (2015). Inflammasome proteins as biomarkers of injury and disease. In General Methods in Biomarker Research and their Applications (pp. 1207-1228). Springer Netherlands. https://doi.org/10.1007/978-94-007-7696-8_4

Inflammasome proteins as biomarkers of injury and disease. / de Rivero Vaccari, Juan Pablo P; de Rivero Vaccari, Juan Carlos.

General Methods in Biomarker Research and their Applications. Springer Netherlands, 2015. p. 1207-1228.

Research output: Chapter in Book/Report/Conference proceedingChapter

de Rivero Vaccari, JPP & de Rivero Vaccari, JC 2015, Inflammasome proteins as biomarkers of injury and disease. in General Methods in Biomarker Research and their Applications. Springer Netherlands, pp. 1207-1228. https://doi.org/10.1007/978-94-007-7696-8_4
de Rivero Vaccari JPP, de Rivero Vaccari JC. Inflammasome proteins as biomarkers of injury and disease. In General Methods in Biomarker Research and their Applications. Springer Netherlands. 2015. p. 1207-1228 https://doi.org/10.1007/978-94-007-7696-8_4
de Rivero Vaccari, Juan Pablo P ; de Rivero Vaccari, Juan Carlos. / Inflammasome proteins as biomarkers of injury and disease. General Methods in Biomarker Research and their Applications. Springer Netherlands, 2015. pp. 1207-1228
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