Infiltration patterns in monoclonal plasma cell disorders: Correlation of magnetic resonance imaging with matched bone marrow histology

Mindaugas Andrulis, Tobias Bäuerle, Hartmut Goldschmidt, Stefan Delorme, Ola Landgren, Peter Schirmacher, Jens Hillengass

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Objectives To investigate how plasma cell infiltration patterns detected by MRI match the plasma cell distribution in bone marrow biopsy. Methods We assessed 50 patients with monoclonal plasma cell disorders of all clinical stages. MRI infiltration pattern was compared with matched BM histology from the same anatomic region. Results MRI revealed a minimal (n = 11, 22%), focal (n = 5, 10%), diffuse (n = 14, 28%) and mixed (n = 20, 40%) infiltration pattern. Diffuse MRI pattern was predominant in smoldering myeloma patients whereas the MRI patterns with "focal component" (i.e. focal and mixed) were most common in symptomatic myeloma (p < 0.01). In histology an interstitial (n = 13, 26%), nodular (n = 23, 46%) and packed marrow (n = 14, 28%) was found respectively. All three histological types of infiltration were observed in patients with diffuse and mixed MRI patterns. Minimal MRI pattern was found in all MGUS patients and was associated with an interstitial BM infiltration. In two patients with minimal MRI pattern an extensive micro-nodular BM infiltration was found in histology. Conclusions Infiltration patterns in MRI represent different histological growth patterns of plasma cells, but the MRI resolution is not sufficient to visualize micro-nodular aggregates of plasma cells.

Original languageEnglish (US)
Pages (from-to)970-974
Number of pages5
JournalEuropean Journal of Radiology
Volume83
Issue number6
DOIs
StatePublished - Jun 2014
Externally publishedYes

Keywords

  • Bone marrow
  • Histology
  • Magnetic resonance imaging
  • Multiple myeloma
  • Paraproteinemias
  • Plasma cells

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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