Abstract
AIM: To determine whether inferior injections had a higher incidence of post-injection endophthalmitis than superior injections. The incidence of endophthalmitis is higher for inferior than superior trabeculectomy filtering blebs, possibly due to bacteria pooling in the inferior tear lake. METHODS: A practice-wide database of endophthalmitis cases identified 5 occurring during the two-year study period. A retrospective review of 8 672 injections in 1 121 eyes of 909 patients treated during the same two-year study period was performed in order to assess the injection site location. RESULTS: Five eyes developed presumed infectious endophthalmitis. Eighty percent of endophthalmitis cases were injected inferiorly, even though 84.6% of the total cohort was injected superiorly. The odds ratio of infection associated with inferior injection location is 22.1 (P=0.006). CONCLUSION: Endophthalmitis after intravitreal injection is rare, occurring in only 0.025% of injections overall. Avoiding intravitreal injections in the inferior quadrants may further reduce the rate of endophthalmitis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 750-754 |
| Number of pages | 5 |
| Journal | International Eye Science |
| Volume | 15 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 8 2015 |
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Keywords
- Anti-VEGF therapy
- Endophthalmitis
- Intravitreal injection site
ASJC Scopus subject areas
- Ophthalmology
Cite this
Inferior intravitreal injection site associated with a higher incidence of post-injection endophthalmitis. / Jonna, Gowtham; Roth, Daniel B.; Fine, Howard F.; Wheatley, H. Matthew; Prenner, Jonathan L.; Kheterpal, Arvin; Cohen, Suzanne; Feuer, William J.
In: International Eye Science, Vol. 15, No. 5, 08.05.2015, p. 750-754.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inferior intravitreal injection site associated with a higher incidence of post-injection endophthalmitis
AU - Jonna, Gowtham
AU - Roth, Daniel B.
AU - Fine, Howard F.
AU - Wheatley, H. Matthew
AU - Prenner, Jonathan L.
AU - Kheterpal, Arvin
AU - Cohen, Suzanne
AU - Feuer, William J
PY - 2015/5/8
Y1 - 2015/5/8
N2 - AIM: To determine whether inferior injections had a higher incidence of post-injection endophthalmitis than superior injections. The incidence of endophthalmitis is higher for inferior than superior trabeculectomy filtering blebs, possibly due to bacteria pooling in the inferior tear lake. METHODS: A practice-wide database of endophthalmitis cases identified 5 occurring during the two-year study period. A retrospective review of 8 672 injections in 1 121 eyes of 909 patients treated during the same two-year study period was performed in order to assess the injection site location. RESULTS: Five eyes developed presumed infectious endophthalmitis. Eighty percent of endophthalmitis cases were injected inferiorly, even though 84.6% of the total cohort was injected superiorly. The odds ratio of infection associated with inferior injection location is 22.1 (P=0.006). CONCLUSION: Endophthalmitis after intravitreal injection is rare, occurring in only 0.025% of injections overall. Avoiding intravitreal injections in the inferior quadrants may further reduce the rate of endophthalmitis.
AB - AIM: To determine whether inferior injections had a higher incidence of post-injection endophthalmitis than superior injections. The incidence of endophthalmitis is higher for inferior than superior trabeculectomy filtering blebs, possibly due to bacteria pooling in the inferior tear lake. METHODS: A practice-wide database of endophthalmitis cases identified 5 occurring during the two-year study period. A retrospective review of 8 672 injections in 1 121 eyes of 909 patients treated during the same two-year study period was performed in order to assess the injection site location. RESULTS: Five eyes developed presumed infectious endophthalmitis. Eighty percent of endophthalmitis cases were injected inferiorly, even though 84.6% of the total cohort was injected superiorly. The odds ratio of infection associated with inferior injection location is 22.1 (P=0.006). CONCLUSION: Endophthalmitis after intravitreal injection is rare, occurring in only 0.025% of injections overall. Avoiding intravitreal injections in the inferior quadrants may further reduce the rate of endophthalmitis.
KW - Anti-VEGF therapy
KW - Endophthalmitis
KW - Intravitreal injection site
UR - http://www.scopus.com/inward/record.url?scp=84929623492&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84929623492&partnerID=8YFLogxK
U2 - 10.3980/j.issn.1672-5123.2015.5.02
DO - 10.3980/j.issn.1672-5123.2015.5.02
M3 - Article
AN - SCOPUS:84929623492
VL - 15
SP - 750
EP - 754
JO - International Eye Science
JF - International Eye Science
SN - 1672-5123
IS - 5
ER -