Inferior intravitreal injection site associated with a higher incidence of post-injection endophthalmitis

Gowtham Jonna, Daniel B. Roth, Howard F. Fine, H. Matthew Wheatley, Jonathan L. Prenner, Arvin Kheterpal, Suzanne Cohen, William J Feuer

Research output: Contribution to journalArticle

Abstract

AIM: To determine whether inferior injections had a higher incidence of post-injection endophthalmitis than superior injections. The incidence of endophthalmitis is higher for inferior than superior trabeculectomy filtering blebs, possibly due to bacteria pooling in the inferior tear lake. METHODS: A practice-wide database of endophthalmitis cases identified 5 occurring during the two-year study period. A retrospective review of 8 672 injections in 1 121 eyes of 909 patients treated during the same two-year study period was performed in order to assess the injection site location. RESULTS: Five eyes developed presumed infectious endophthalmitis. Eighty percent of endophthalmitis cases were injected inferiorly, even though 84.6% of the total cohort was injected superiorly. The odds ratio of infection associated with inferior injection location is 22.1 (P=0.006). CONCLUSION: Endophthalmitis after intravitreal injection is rare, occurring in only 0.025% of injections overall. Avoiding intravitreal injections in the inferior quadrants may further reduce the rate of endophthalmitis.

Original languageEnglish (US)
Pages (from-to)750-754
Number of pages5
JournalInternational Eye Science
Volume15
Issue number5
DOIs
StatePublished - May 8 2015

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Intravitreal Injections
Endophthalmitis
Injections
Incidence
Trabeculectomy
Blister
Lakes
Tears
Odds Ratio
Databases
Bacteria
Infection

Keywords

  • Anti-VEGF therapy
  • Endophthalmitis
  • Intravitreal injection site

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Jonna, G., Roth, D. B., Fine, H. F., Wheatley, H. M., Prenner, J. L., Kheterpal, A., ... Feuer, W. J. (2015). Inferior intravitreal injection site associated with a higher incidence of post-injection endophthalmitis. International Eye Science, 15(5), 750-754. https://doi.org/10.3980/j.issn.1672-5123.2015.5.02

Inferior intravitreal injection site associated with a higher incidence of post-injection endophthalmitis. / Jonna, Gowtham; Roth, Daniel B.; Fine, Howard F.; Wheatley, H. Matthew; Prenner, Jonathan L.; Kheterpal, Arvin; Cohen, Suzanne; Feuer, William J.

In: International Eye Science, Vol. 15, No. 5, 08.05.2015, p. 750-754.

Research output: Contribution to journalArticle

Jonna, G, Roth, DB, Fine, HF, Wheatley, HM, Prenner, JL, Kheterpal, A, Cohen, S & Feuer, WJ 2015, 'Inferior intravitreal injection site associated with a higher incidence of post-injection endophthalmitis', International Eye Science, vol. 15, no. 5, pp. 750-754. https://doi.org/10.3980/j.issn.1672-5123.2015.5.02
Jonna, Gowtham ; Roth, Daniel B. ; Fine, Howard F. ; Wheatley, H. Matthew ; Prenner, Jonathan L. ; Kheterpal, Arvin ; Cohen, Suzanne ; Feuer, William J. / Inferior intravitreal injection site associated with a higher incidence of post-injection endophthalmitis. In: International Eye Science. 2015 ; Vol. 15, No. 5. pp. 750-754.
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