Abstract
Purpose: To elucidate risk factors, microbial culture results, and visual outcomes for infectious keratitis after photorefractive keratectomy (PRK). Design: Multicenter, retrospective chart review, case report, and literature review. Methods: The records of 12 patients with infectious keratitis after PRK were reviewed. Main Outcome Measures: Causative organism, response to medical treatment, and visual outcome. Results: Infectious keratitis developed in 13 eyes of 12 patients after PRK. Organisms cultured were Staphylococcus aureus (n = 5), including a bilateral case of methicillin-resistant Staphylococcus aureus; Staphylococcus epidermidis (n = 4); Streptococcus pneumoniae (n = 3); and Streptococcus viridans (n = 1). Four patients manipulated their contact lenses, and 2 patients were exposed to nosocomial organisms while working in a hospital environment. Prophylactic antibiotics used were tobramycin (nine cases), polymyxin B-trimethoprim (three cases), and ciprofloxacin (one case). Final best spectacle-corrected visual acuity ranged from 20/20 to 20/100. Conclusions: Infectious corneal ulceration is a serious potential complication of PRK. Gram-positive organisms are the most common pathogens. Antibiotic prophylaxis should be broad spectrum and should include gram-positive coverage.
| Original language | English |
|---|---|
| Pages (from-to) | 743-747 |
| Number of pages | 5 |
| Journal | Ophthalmology |
| Volume | 110 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1 2003 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Ophthalmology
Cite this
Infectious keratitis after photorefractive keratectomy. / Donnenfeld, Eric D.; O'Brien, Terrence; Solomon, Renée; Perry, Henry D.; Speaker, Mark G.; Wittpenn, John.
In: Ophthalmology, Vol. 110, No. 4, 01.04.2003, p. 743-747.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Infectious keratitis after photorefractive keratectomy
AU - Donnenfeld, Eric D.
AU - O'Brien, Terrence
AU - Solomon, Renée
AU - Perry, Henry D.
AU - Speaker, Mark G.
AU - Wittpenn, John
PY - 2003/4/1
Y1 - 2003/4/1
N2 - Purpose: To elucidate risk factors, microbial culture results, and visual outcomes for infectious keratitis after photorefractive keratectomy (PRK). Design: Multicenter, retrospective chart review, case report, and literature review. Methods: The records of 12 patients with infectious keratitis after PRK were reviewed. Main Outcome Measures: Causative organism, response to medical treatment, and visual outcome. Results: Infectious keratitis developed in 13 eyes of 12 patients after PRK. Organisms cultured were Staphylococcus aureus (n = 5), including a bilateral case of methicillin-resistant Staphylococcus aureus; Staphylococcus epidermidis (n = 4); Streptococcus pneumoniae (n = 3); and Streptococcus viridans (n = 1). Four patients manipulated their contact lenses, and 2 patients were exposed to nosocomial organisms while working in a hospital environment. Prophylactic antibiotics used were tobramycin (nine cases), polymyxin B-trimethoprim (three cases), and ciprofloxacin (one case). Final best spectacle-corrected visual acuity ranged from 20/20 to 20/100. Conclusions: Infectious corneal ulceration is a serious potential complication of PRK. Gram-positive organisms are the most common pathogens. Antibiotic prophylaxis should be broad spectrum and should include gram-positive coverage.
AB - Purpose: To elucidate risk factors, microbial culture results, and visual outcomes for infectious keratitis after photorefractive keratectomy (PRK). Design: Multicenter, retrospective chart review, case report, and literature review. Methods: The records of 12 patients with infectious keratitis after PRK were reviewed. Main Outcome Measures: Causative organism, response to medical treatment, and visual outcome. Results: Infectious keratitis developed in 13 eyes of 12 patients after PRK. Organisms cultured were Staphylococcus aureus (n = 5), including a bilateral case of methicillin-resistant Staphylococcus aureus; Staphylococcus epidermidis (n = 4); Streptococcus pneumoniae (n = 3); and Streptococcus viridans (n = 1). Four patients manipulated their contact lenses, and 2 patients were exposed to nosocomial organisms while working in a hospital environment. Prophylactic antibiotics used were tobramycin (nine cases), polymyxin B-trimethoprim (three cases), and ciprofloxacin (one case). Final best spectacle-corrected visual acuity ranged from 20/20 to 20/100. Conclusions: Infectious corneal ulceration is a serious potential complication of PRK. Gram-positive organisms are the most common pathogens. Antibiotic prophylaxis should be broad spectrum and should include gram-positive coverage.
UR - http://www.scopus.com/inward/record.url?scp=0242416974&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0242416974&partnerID=8YFLogxK
U2 - 10.1016/S0161-6420(02)01936-X
DO - 10.1016/S0161-6420(02)01936-X
M3 - Article
C2 - 12689896
AN - SCOPUS:0242416974
VL - 110
SP - 743
EP - 747
JO - Ophthalmology
JF - Ophthalmology
SN - 0161-6420
IS - 4
ER -