Abstract
There have been numerous advances in both the diagnosis and management of infectious endophthalmitis. The recently published results of the Endophthalmitis Vitrectomy Study further added to our understanding of the microbiological features, clinical course, and management of postoperative infectious endophthalmitis. The Endophthalmitis Vitrectomy Study confirmed that the Gram-positive coagulase-negative organisms are the most common cause of acute endophthalmitis after cataract or secondary intraocular lens surgery. The Endophthalmitis Vitrectomy Study also confirmed the efficacy of treatment with intravitreal vancomycin and amikacin. In this study, an immediate pars plana vitrectomy yielded better visual acuity outcomes when compared with a vitreous aspiration or biopsy in eyes with light-perception-only vision. The study did not demonstrate a difference between groups (vitrectomy versus tap/biopsy) in eyes with better than light-perception-only visual acuity. Finally, the study demonstrated that in the Endophthalmitis Vitrectomy Study systemic antibiotics (amikacin and ceftazidime) were not of benefit judged by the outcome of final visual acuity and media clarity. Newer, less toxic, antifungal agents with good intraocular penetration are available to supplement the treatment of endogenous fungal endophthalmitis.
| Original language | English |
|---|---|
| Pages (from-to) | 153-162 |
| Number of pages | 10 |
| Journal | Current Opinion in Infectious Diseases |
| Volume | 10 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 19 1997 |
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ASJC Scopus subject areas
- Microbiology (medical)
- Immunology
Cite this
Infectious endophthalmitis. / Brod, Roy D.; Flynn, Harry W.
In: Current Opinion in Infectious Diseases, Vol. 10, No. 2, 19.06.1997, p. 153-162.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Infectious endophthalmitis
AU - Brod, Roy D.
AU - Flynn, Harry W
PY - 1997/6/19
Y1 - 1997/6/19
N2 - There have been numerous advances in both the diagnosis and management of infectious endophthalmitis. The recently published results of the Endophthalmitis Vitrectomy Study further added to our understanding of the microbiological features, clinical course, and management of postoperative infectious endophthalmitis. The Endophthalmitis Vitrectomy Study confirmed that the Gram-positive coagulase-negative organisms are the most common cause of acute endophthalmitis after cataract or secondary intraocular lens surgery. The Endophthalmitis Vitrectomy Study also confirmed the efficacy of treatment with intravitreal vancomycin and amikacin. In this study, an immediate pars plana vitrectomy yielded better visual acuity outcomes when compared with a vitreous aspiration or biopsy in eyes with light-perception-only vision. The study did not demonstrate a difference between groups (vitrectomy versus tap/biopsy) in eyes with better than light-perception-only visual acuity. Finally, the study demonstrated that in the Endophthalmitis Vitrectomy Study systemic antibiotics (amikacin and ceftazidime) were not of benefit judged by the outcome of final visual acuity and media clarity. Newer, less toxic, antifungal agents with good intraocular penetration are available to supplement the treatment of endogenous fungal endophthalmitis.
AB - There have been numerous advances in both the diagnosis and management of infectious endophthalmitis. The recently published results of the Endophthalmitis Vitrectomy Study further added to our understanding of the microbiological features, clinical course, and management of postoperative infectious endophthalmitis. The Endophthalmitis Vitrectomy Study confirmed that the Gram-positive coagulase-negative organisms are the most common cause of acute endophthalmitis after cataract or secondary intraocular lens surgery. The Endophthalmitis Vitrectomy Study also confirmed the efficacy of treatment with intravitreal vancomycin and amikacin. In this study, an immediate pars plana vitrectomy yielded better visual acuity outcomes when compared with a vitreous aspiration or biopsy in eyes with light-perception-only vision. The study did not demonstrate a difference between groups (vitrectomy versus tap/biopsy) in eyes with better than light-perception-only visual acuity. Finally, the study demonstrated that in the Endophthalmitis Vitrectomy Study systemic antibiotics (amikacin and ceftazidime) were not of benefit judged by the outcome of final visual acuity and media clarity. Newer, less toxic, antifungal agents with good intraocular penetration are available to supplement the treatment of endogenous fungal endophthalmitis.
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U2 - 10.1097/00001432-199704000-00017
DO - 10.1097/00001432-199704000-00017
M3 - Article
VL - 10
SP - 153
EP - 162
JO - Current Opinion in Infectious Diseases
JF - Current Opinion in Infectious Diseases
SN - 0951-7375
IS - 2
ER -