Infectious Crystalline Keratopathy due to Streptococcus pneumoniae: Possible Association with Serotype

Alice Y. Matoba, Terrence P. O'Brien, Kirk R. Wilhelmus, Dan B. Jones

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Background: Infectious crystalline keratopathy is a distinctive clinical entity characterized by bacterial replication within the cornea without inflammation. The authors report on a patient with infectious crystalline keratopathy due to Streptococcus pneumoniae serotype 11F. They used this isolate to study the contribution of the pneumococcal polysaccharide capsule to the pathogenesis of the infectious crystalline keratopathy. Methods: Aliquots containing 106 colony-forming units of pneumococci serotype 11F, serogroup 9 or 15, were inoculated into New Zealand white rabbit corneas. The corneas were examined at 24, 48, and 72 hours. Representative corneas were excised at 24 hours and processed for histopathologic analysis. Results: Pauci-inflammatory crystalline lesions developed in all corneas inoculated with the serotype 11F ocular isolate by 24 hours. Suppurative keratitis developed in control corneas inoculated with serogroup 9 or 15 pneumococci. The nonocular 11F isolates produced lesions with some features compatible with infectious crystalline keratopathy. Conclusion: Different pneumococcal serotypes vary in their ability to produce infectious crystalline keratopathy. Because serotype differences reflect differences in the antigenic polysaccharides of the bacterial capsule, this study suggests that properties of the pneumococcal capsule may influence the initial development of infectious crystalline keratopathy.

Original languageEnglish (US)
Pages (from-to)1000-1004
Number of pages5
Issue number6
StatePublished - 1994
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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