Abstract
Objective: We hypothesized that infectious burden (IB), a composite serologic measure of exposure to common pathogens (i.e., Chlamydia pneumoniae, Helicobacter pylori, cytomegalovirus, and herpes simplex virus 1 and 2) associated with vascular risk in the prospective Northern Manhattan Study (NOMAS), would also be associated with cognition. Methods: Cognition was assessed using the Mini-Mental State Examination (MMSE) at enrollment and the modified Telephone Interview for Cognitive Status (TICS-m) at annual follow-up visits. Adjusted linear and logistic regressions were used to measure the association between IB index and MMSE. Generalized estimating equation models were used to evaluate associations with TICS-m and its change over time. Results: Serologies and cognitive assessments were available in 1,625 participants of the NOMAS cohort. In unadjusted analyses, higher IB index was associated with worse cognition (change per standard deviation [SD] of IB for MMSE was 20.77, p < 0.0001, and for first measurements of TICS-m was 21.89, p < 0.0001). These effects were attenuated after adjusting for risk factors (for MMSE adjusted change per SD of IB = 20.17, p = 0.06, for TICS-m adjusted change per SD IB = 20.68, p < 0.0001). IB was associated with MMSE ≤24 (compared to MMSE >24, adjusted odds ratio 1.26 per SD of IB, 95% confidence interval 1.06-1.51). IB was not associated with cognitive decline over time. The results were similar when IB was limited to viral serologies only. Conclusion: A measure of IB associated with stroke risk and atherosclerosis was independently associated with cognitive performance in this multiethnic cohort. Past infections may contribute to cognitive impairment.
| Original language | English |
|---|---|
| Pages (from-to) | 1209-1215 |
| Number of pages | 7 |
| Journal | Neurology |
| Volume | 80 |
| Issue number | 13 |
| DOIs | |
| State | Published - Mar 26 2013 |
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ASJC Scopus subject areas
- Clinical Neurology
- Arts and Humanities (miscellaneous)
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Infectious burden and cognitive function : The Northern Manhattan Study. / Katan, Mira; Moon, Yeseon Park; Paik, Myunghee Cho; Sacco, Ralph L; Wright, Clinton B; Elkind, Mitchell S V.
In: Neurology, Vol. 80, No. 13, 26.03.2013, p. 1209-1215.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Infectious burden and cognitive function
T2 - The Northern Manhattan Study
AU - Katan, Mira
AU - Moon, Yeseon Park
AU - Paik, Myunghee Cho
AU - Sacco, Ralph L
AU - Wright, Clinton B
AU - Elkind, Mitchell S V
PY - 2013/3/26
Y1 - 2013/3/26
N2 - Objective: We hypothesized that infectious burden (IB), a composite serologic measure of exposure to common pathogens (i.e., Chlamydia pneumoniae, Helicobacter pylori, cytomegalovirus, and herpes simplex virus 1 and 2) associated with vascular risk in the prospective Northern Manhattan Study (NOMAS), would also be associated with cognition. Methods: Cognition was assessed using the Mini-Mental State Examination (MMSE) at enrollment and the modified Telephone Interview for Cognitive Status (TICS-m) at annual follow-up visits. Adjusted linear and logistic regressions were used to measure the association between IB index and MMSE. Generalized estimating equation models were used to evaluate associations with TICS-m and its change over time. Results: Serologies and cognitive assessments were available in 1,625 participants of the NOMAS cohort. In unadjusted analyses, higher IB index was associated with worse cognition (change per standard deviation [SD] of IB for MMSE was 20.77, p < 0.0001, and for first measurements of TICS-m was 21.89, p < 0.0001). These effects were attenuated after adjusting for risk factors (for MMSE adjusted change per SD of IB = 20.17, p = 0.06, for TICS-m adjusted change per SD IB = 20.68, p < 0.0001). IB was associated with MMSE ≤24 (compared to MMSE >24, adjusted odds ratio 1.26 per SD of IB, 95% confidence interval 1.06-1.51). IB was not associated with cognitive decline over time. The results were similar when IB was limited to viral serologies only. Conclusion: A measure of IB associated with stroke risk and atherosclerosis was independently associated with cognitive performance in this multiethnic cohort. Past infections may contribute to cognitive impairment.
AB - Objective: We hypothesized that infectious burden (IB), a composite serologic measure of exposure to common pathogens (i.e., Chlamydia pneumoniae, Helicobacter pylori, cytomegalovirus, and herpes simplex virus 1 and 2) associated with vascular risk in the prospective Northern Manhattan Study (NOMAS), would also be associated with cognition. Methods: Cognition was assessed using the Mini-Mental State Examination (MMSE) at enrollment and the modified Telephone Interview for Cognitive Status (TICS-m) at annual follow-up visits. Adjusted linear and logistic regressions were used to measure the association between IB index and MMSE. Generalized estimating equation models were used to evaluate associations with TICS-m and its change over time. Results: Serologies and cognitive assessments were available in 1,625 participants of the NOMAS cohort. In unadjusted analyses, higher IB index was associated with worse cognition (change per standard deviation [SD] of IB for MMSE was 20.77, p < 0.0001, and for first measurements of TICS-m was 21.89, p < 0.0001). These effects were attenuated after adjusting for risk factors (for MMSE adjusted change per SD of IB = 20.17, p = 0.06, for TICS-m adjusted change per SD IB = 20.68, p < 0.0001). IB was associated with MMSE ≤24 (compared to MMSE >24, adjusted odds ratio 1.26 per SD of IB, 95% confidence interval 1.06-1.51). IB was not associated with cognitive decline over time. The results were similar when IB was limited to viral serologies only. Conclusion: A measure of IB associated with stroke risk and atherosclerosis was independently associated with cognitive performance in this multiethnic cohort. Past infections may contribute to cognitive impairment.
UR - http://www.scopus.com/inward/record.url?scp=84876240359&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84876240359&partnerID=8YFLogxK
U2 - 10.1212/WNL.0b013e3182896e79
DO - 10.1212/WNL.0b013e3182896e79
M3 - Article
VL - 80
SP - 1209
EP - 1215
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 13
ER -