Purpose of Review: There has been an exponential expansion of the types and application of ocular prostheses in the last 10ï¿½years. Patients with ocular prostheses in all forms are at increased risk for microbial infections. The true incidence and/or prevalence of ocular prosthesis-associated infections are unknown. Recent Findings: Millions of people worldwide are candidates in need of ocular prostheses for cosmesis, vision rehabilitation, and restoration. The presence of an ocular prosthesis carries a lifetime risk of infection and leads to ocular surface and microbiome dysbiosis. Summary: Ophthalmologists should be aware of the inherent risk and diversity of microbial colonization and infections associated with the placement of the expanding list of ocular prostheses. Additional adverse events include ocular surface and ocular microbiome disruption, vision loss, and ocular surface dysfunction.
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