Abstract
Thirty autopsies performed on infants and children with HIV infection and/or AIDS were reviewed for the presence and type of infection. Twenty-six (87%) demonstrated evidence of infection in addition to HIV at the time of postmortem examination. Pathogenic bacterial infections were the most frequently encountered, seen in 15 of the cases. Nine of the 15 (60%) were due to gram-negative rods, most commonly Pseudomonas aeruginosa. Infections with gram-negative organisms often involved multiple organ systems and were frequently undiagnosed both pre -and postmortem because of variability in culture results and difficulties in identification both clinically and in tissue sections. Discussion is presented of unusual staining characteristics and filamentous morphology found with these pathogens. Other pathogenic bacteria encountered were Klebsiella pneumoniae, Escherichia coli, Enterobacter sp., and Staphylococcus. Fungal infections due to Candida species were present in nine cases (31 %) but were invasive in only two of these. One instance of Aspergillus meningo-encephalitis was noted. Proven viral infections were present in five children (three cytomegalovirus, one herpes simplex, and one adenovirus). Pneumocystis carinii pneumonia was diagnosed in five of the patients (17%), and one instance of disseminated Mycobacterium avium-intracellulare was encountered..
| Original language | English |
|---|---|
| Pages (from-to) | 269-281 |
| Number of pages | 13 |
| Journal | Fetal and Pediatric Pathology |
| Volume | 15 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 1995 |
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Keywords
- Abscess
- AIDS
- Autopsy
- Gram-negative
- HIV
- Infection
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Pediatrics, Perinatology, and Child Health
Cite this
Infections in children with human immunodeficiency virus/acquired immunodeficiency syndrome : An autopsy study of 30 cases in south Florida, 1990-1993. / Reik, Rita A.; Rodriguez, Maria; Hensley, George T.
In: Fetal and Pediatric Pathology, Vol. 15, No. 2, 01.01.1995, p. 269-281.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Infections in children with human immunodeficiency virus/acquired immunodeficiency syndrome
T2 - An autopsy study of 30 cases in south Florida, 1990-1993
AU - Reik, Rita A.
AU - Rodriguez, Maria
AU - Hensley, George T.
PY - 1995/1/1
Y1 - 1995/1/1
N2 - Thirty autopsies performed on infants and children with HIV infection and/or AIDS were reviewed for the presence and type of infection. Twenty-six (87%) demonstrated evidence of infection in addition to HIV at the time of postmortem examination. Pathogenic bacterial infections were the most frequently encountered, seen in 15 of the cases. Nine of the 15 (60%) were due to gram-negative rods, most commonly Pseudomonas aeruginosa. Infections with gram-negative organisms often involved multiple organ systems and were frequently undiagnosed both pre -and postmortem because of variability in culture results and difficulties in identification both clinically and in tissue sections. Discussion is presented of unusual staining characteristics and filamentous morphology found with these pathogens. Other pathogenic bacteria encountered were Klebsiella pneumoniae, Escherichia coli, Enterobacter sp., and Staphylococcus. Fungal infections due to Candida species were present in nine cases (31 %) but were invasive in only two of these. One instance of Aspergillus meningo-encephalitis was noted. Proven viral infections were present in five children (three cytomegalovirus, one herpes simplex, and one adenovirus). Pneumocystis carinii pneumonia was diagnosed in five of the patients (17%), and one instance of disseminated Mycobacterium avium-intracellulare was encountered..
AB - Thirty autopsies performed on infants and children with HIV infection and/or AIDS were reviewed for the presence and type of infection. Twenty-six (87%) demonstrated evidence of infection in addition to HIV at the time of postmortem examination. Pathogenic bacterial infections were the most frequently encountered, seen in 15 of the cases. Nine of the 15 (60%) were due to gram-negative rods, most commonly Pseudomonas aeruginosa. Infections with gram-negative organisms often involved multiple organ systems and were frequently undiagnosed both pre -and postmortem because of variability in culture results and difficulties in identification both clinically and in tissue sections. Discussion is presented of unusual staining characteristics and filamentous morphology found with these pathogens. Other pathogenic bacteria encountered were Klebsiella pneumoniae, Escherichia coli, Enterobacter sp., and Staphylococcus. Fungal infections due to Candida species were present in nine cases (31 %) but were invasive in only two of these. One instance of Aspergillus meningo-encephalitis was noted. Proven viral infections were present in five children (three cytomegalovirus, one herpes simplex, and one adenovirus). Pneumocystis carinii pneumonia was diagnosed in five of the patients (17%), and one instance of disseminated Mycobacterium avium-intracellulare was encountered..
KW - Abscess
KW - AIDS
KW - Autopsy
KW - Gram-negative
KW - HIV
KW - Infection
UR - http://www.scopus.com/inward/record.url?scp=0029040753&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029040753&partnerID=8YFLogxK
U2 - 10.3109/15513819509026962
DO - 10.3109/15513819509026962
M3 - Article
C2 - 8597814
AN - SCOPUS:0029040753
VL - 15
SP - 269
EP - 281
JO - Fetal and Pediatric Pathology
JF - Fetal and Pediatric Pathology
SN - 1551-3815
IS - 2
ER -