Infection of a yellow baboon with simian immunodeficiency virus from African green monkeys

Evidence for cross-species transmission in the wild

Mojun J. Jin, Jeffrey Rogers, Jane E. Phillips-Conroy, Jonathan S. Allan, Ronald Charles Desrosiers, George M. Shaw, Paul M. Sharp, Beatrice H. Hahn

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

Many African primates are known to be naturally infected with simian immunodeficiency viruses (SIVs), but only a fraction of these viruses has been molecularly characterized. One primate species for which only serological evidence of SIV infection has been reported is the yellow baboon (Papio hamadryas cynocephalus). Two wild-living baboons with strong SIV(AGM) seroreactivity were previously identified in a Tanzanian national park where baboons and African green monkeys shared the same habitat (T. Kodama, D. P. Silva, M. D. Daniel, J. E. Phillips-Conroy, C. J. Jolly, J. Rogers, and R. C. Desrosiers, AIDS Res. Hum. Retroviruses 5:337-343, 1989). To determine the genetic identity of the viruses infecting these animals, we used PCR to examine SIV sequences directly in uncultured leukocyte DNA. Targeting two different, nonoverlapping genomic regions, we amplified and sequenced a 673- bp gag gene fragment and a 908-bp env gene fragment from one of the two baboons. Phylo-genetic analyses revealed that this baboon was infected with an SIV(AGM) strain of the vervet subtype. These results provide the first direct evidence for simian-to-simian cross-species transmission of SIV in the wild.

Original languageEnglish (US)
Pages (from-to)8454-8460
Number of pages7
JournalJournal of Virology
Volume68
Issue number12
StatePublished - Dec 1994
Externally publishedYes

Fingerprint

Papio cynocephalus
Simian immunodeficiency virus
Cercopithecus aethiops
Simian Immunodeficiency Virus
Papio
Infection
infection
Primates
Retroviridae
Papio hamadryas
gag Genes
Viruses
env Genes
viruses
Virus Diseases
Pedigree
Ecosystem
leukocytes
national parks
Acquired Immunodeficiency Syndrome

ASJC Scopus subject areas

  • Immunology

Cite this

Jin, M. J., Rogers, J., Phillips-Conroy, J. E., Allan, J. S., Desrosiers, R. C., Shaw, G. M., ... Hahn, B. H. (1994). Infection of a yellow baboon with simian immunodeficiency virus from African green monkeys: Evidence for cross-species transmission in the wild. Journal of Virology, 68(12), 8454-8460.

Infection of a yellow baboon with simian immunodeficiency virus from African green monkeys : Evidence for cross-species transmission in the wild. / Jin, Mojun J.; Rogers, Jeffrey; Phillips-Conroy, Jane E.; Allan, Jonathan S.; Desrosiers, Ronald Charles; Shaw, George M.; Sharp, Paul M.; Hahn, Beatrice H.

In: Journal of Virology, Vol. 68, No. 12, 12.1994, p. 8454-8460.

Research output: Contribution to journalArticle

Jin, MJ, Rogers, J, Phillips-Conroy, JE, Allan, JS, Desrosiers, RC, Shaw, GM, Sharp, PM & Hahn, BH 1994, 'Infection of a yellow baboon with simian immunodeficiency virus from African green monkeys: Evidence for cross-species transmission in the wild', Journal of Virology, vol. 68, no. 12, pp. 8454-8460.
Jin, Mojun J. ; Rogers, Jeffrey ; Phillips-Conroy, Jane E. ; Allan, Jonathan S. ; Desrosiers, Ronald Charles ; Shaw, George M. ; Sharp, Paul M. ; Hahn, Beatrice H. / Infection of a yellow baboon with simian immunodeficiency virus from African green monkeys : Evidence for cross-species transmission in the wild. In: Journal of Virology. 1994 ; Vol. 68, No. 12. pp. 8454-8460.
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