Infection in infancy and subsequent risk of developing lymphoma in children and young adults

Lynn R. Goldin, Ola Landgren, Sigurdur Y. Kristinsson, Magnus Björkholm, Ora Paltiel

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

There is evidence that certain infections and autoimmunity predispose to the development of non-Hodgkin lymphomas (NHLs). A previous study reported that hospitalization for infections in infancy led to an increased risk of NHL. By using population-based registries in Sweden, we compared the rate of hospitalization for infections in infancy between lymphoma cases and matched controls for patients born since 1964. A history of infection was associated with a significantly increased risk of aggressive B-cell lymphomas (odds ratio 2.1, 95% confidence interval 1.11-4.04, P = .02). The specific infections involved were respiratory and intestinal. No effects were observed among cases of Hodgkin lymphoma. This association could result from the infection, its treatment, or could be a surrogate marker for underlying immune defects. Further studies are needed to determine whether this association is present among NHL occurring in older adults and if improved survival of patients with immune defects has contributed to the secular increases in incidence of NHLs.

Original languageEnglish (US)
Pages (from-to)1670-1672
Number of pages3
JournalBlood
Volume117
Issue number5
DOIs
StatePublished - Feb 3 2011
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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