Infantile midline facial hemangioma with agenesis of the corpus callosum and sinus pericranii: Another face of the PHACE syndrome

Anna Drosou, Latanya Benjamin, Italo Linfante, Karen Mallin, Andrea Trowers, Ajay K. Wakhloo, Seth Thaller, Lawrence A Schachner

Research output: Contribution to journalArticle

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Abstract

Background: In the majority of cases, infantile hemangiomas are not associated with any other abnormalities. Occasionally, they may indicate the presence of systemic malformations. PHACE syndrome includes the coexistence of hemangioma, posterior fossa brain abnormalities, arterial anomalies, coarctation of the aorta, cardiac defects, and eye abnormalities. We report a case of a 2-month-old female with PHACE syndrome who also had sinus pericranii. Clinical case: A 2-month-old girl was seen for a plaque-like, segmental, midfacial hemangioma, with recurrent hemorrhages, noted at birth. As part of the PHACE syndrome, she had a midline facial hemangioma, absent corpus callosum, hypoplastic internal carotid artery, and an abnormal tortuous dysplastic basilar artery. Digital subtraction angiography showed sinus pericranii. The patient underwent successful endovascular embolization of the hemangioma that prevented further bleeding. Conclusion: Sinus pericranii is a rare finding that has not, to our knowledge, been previously associated with PHACE syndrome. Central nervous system, not only posterior fossa, abnormalities are frequently encountered in PHACE syndrome. Endovascular embolization of the facial hemangioma in our patient was a useful therapy.

Original languageEnglish
Pages (from-to)348-352
Number of pages5
JournalJournal of the American Academy of Dermatology
Volume54
Issue number2
DOIs
StatePublished - Feb 1 2006

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Sinus Pericranii
Agenesis of Corpus Callosum
Hemangioma
Eye Abnormalities
Hemorrhage
Basilar Artery
Digital Subtraction Angiography
Aortic Coarctation
Corpus Callosum
Internal Carotid Artery
varespladib methyl
Central Nervous System
Parturition
Brain

ASJC Scopus subject areas

  • Dermatology

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Infantile midline facial hemangioma with agenesis of the corpus callosum and sinus pericranii : Another face of the PHACE syndrome. / Drosou, Anna; Benjamin, Latanya; Linfante, Italo; Mallin, Karen; Trowers, Andrea; Wakhloo, Ajay K.; Thaller, Seth; Schachner, Lawrence A.

In: Journal of the American Academy of Dermatology, Vol. 54, No. 2, 01.02.2006, p. 348-352.

Research output: Contribution to journalArticle

Drosou, Anna ; Benjamin, Latanya ; Linfante, Italo ; Mallin, Karen ; Trowers, Andrea ; Wakhloo, Ajay K. ; Thaller, Seth ; Schachner, Lawrence A. / Infantile midline facial hemangioma with agenesis of the corpus callosum and sinus pericranii : Another face of the PHACE syndrome. In: Journal of the American Academy of Dermatology. 2006 ; Vol. 54, No. 2. pp. 348-352.
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