INFANT FORMULA AS A CAUSE OF ALUMINIUM TOXICITY IN NEONATAL URAEMIA

Michael Freundlich, Carolyn Abitbol, Gaston Zilleruelo, Jose Strauss, Marie Claude Faugere, Hartmut H. Malluche

Research output: Contribution to journalArticle

85 Scopus citations

Abstract

Aluminium toxicity occurred in two infants with congenital uraemia who had never received phosphate binders or other aluminium-containing agents or intravenous fluids. One patient was treated by peritoneal dialysis from the age of two weeks and died at three months after the sudden onset of neurological symptoms; the other died after one month of conservative management without dialysis. Brain aluminium concentration was high in both infants (6·4 and 47 μg/g, respectively) whereas bone aluminium content was normal and there were no histological changes or stainable aluminium on bone biopsy specimens. Both infants were fed with 'Similac PM 60/40'. To investigate possible sources of aluminium, powdered milk formula, sterilised water used for preparation of the feed, and dialysate concentrate (first patient) were analysed. Aluminium concentration was high (232±60 ng/ml) in powdered milk but negligible in sterilised water and dialysate concentrate (4 ng/ml and 3·4±2·4 ng/ml, respectively). These findings indicate that proprietary infant milk formula is another source of aluminium. Aluminium-free milk should contribute to the prevention of aluminium toxicity in infants with renal failure.

Original languageEnglish (US)
Pages (from-to)527-529
Number of pages3
JournalThe Lancet
Volume326
Issue number8454
DOIs
StatePublished - Sep 7 1985

ASJC Scopus subject areas

  • Medicine(all)

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