Induction of spinal NADPH-diaphorase by nerve injury is attenuated by adrenal medullary transplants

Aldric T. Hama, Jacqueline Sagen

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Persistent sensory abnormalities consequent to injury may involve prolonged neuroplastic changes in the spinal cord similar to those in long-term potentiation. Molecular markers, like the putative nitric oxide synthase, nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d), can be useful indicators of increased neuronal activity. Peripheral nerve injury markedly increased NADPH-d-labeling in sensory regions of the spinal cord, paralleling induction of abnormal pain (hyperalgesia). Both NADPH-d activation and hyperalgesia were reversed by transplantation of opioid/catecholamine-producing adrenal medullary tissue into the spinal subarachnoid space. These results suggest that adrenal medullary transplants can attenuate abnormal neuronal activity consequent to injury.

Original languageEnglish (US)
Pages (from-to)345-351
Number of pages7
JournalBrain Research
Volume640
Issue number1-2
DOIs
StatePublished - Mar 21 1994
Externally publishedYes

Keywords

  • Chromaffin cell
  • Hyperalgesia
  • Neural transplantation
  • Neuropathic pain
  • Nitric oxide
  • Spinal cord

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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