Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement

Victor L Perez Quinones, Luk Van Parijs, Andre Biuckians, Xin Xiao Zheng, Terry B. Strom, Abul K. Abbas

Research output: Contribution to journalArticle

608 Citations (Scopus)

Abstract

Studies of T cell anergy in vitro have led to the widely accepted view that anergy is induced by T cell antigen recognition without costimulation. We show that the induction of T cell anergy in vivo is due to an abortive T cell response that requires recognition of 87 molecules, since blocking 87 maintains T cells in an unactivated but functionally competent state. Furthermore, the induction of anergy is prevented by blocking CTLA-4, the inhibitory T cell receptor for 87 molecules. Thus, in vivo T cell anergy may be induced not because of a lack of costimulation, but as a result of specific recognition of B7 molecules by CTLA-4. In contrast, blocking CD28 on T cells prevents priming but not the induction of tolerance. Therefore, the outcome of antigen recognition by T cells is determined by the interaction of CD28 or CTLA-4 on the T cells with 87 molecules.

Original languageEnglish
Pages (from-to)411-417
Number of pages7
JournalImmunity
Volume6
Issue number4
StatePublished - Apr 1 1997
Externally publishedYes

Fingerprint

T-Lymphocytes
Costimulatory and Inhibitory T-Cell Receptors
B7 Antigens
Viral Tumor Antigens
Antigens

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

Cite this

Perez Quinones, V. L., Van Parijs, L., Biuckians, A., Zheng, X. X., Strom, T. B., & Abbas, A. K. (1997). Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity, 6(4), 411-417.

Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. / Perez Quinones, Victor L; Van Parijs, Luk; Biuckians, Andre; Zheng, Xin Xiao; Strom, Terry B.; Abbas, Abul K.

In: Immunity, Vol. 6, No. 4, 01.04.1997, p. 411-417.

Research output: Contribution to journalArticle

Perez Quinones, VL, Van Parijs, L, Biuckians, A, Zheng, XX, Strom, TB & Abbas, AK 1997, 'Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement', Immunity, vol. 6, no. 4, pp. 411-417.
Perez Quinones VL, Van Parijs L, Biuckians A, Zheng XX, Strom TB, Abbas AK. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity. 1997 Apr 1;6(4):411-417.
Perez Quinones, Victor L ; Van Parijs, Luk ; Biuckians, Andre ; Zheng, Xin Xiao ; Strom, Terry B. ; Abbas, Abul K. / Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. In: Immunity. 1997 ; Vol. 6, No. 4. pp. 411-417.
@article{ce4ce53df0224a208b4c566d850bf8e0,
title = "Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement",
abstract = "Studies of T cell anergy in vitro have led to the widely accepted view that anergy is induced by T cell antigen recognition without costimulation. We show that the induction of T cell anergy in vivo is due to an abortive T cell response that requires recognition of 87 molecules, since blocking 87 maintains T cells in an unactivated but functionally competent state. Furthermore, the induction of anergy is prevented by blocking CTLA-4, the inhibitory T cell receptor for 87 molecules. Thus, in vivo T cell anergy may be induced not because of a lack of costimulation, but as a result of specific recognition of B7 molecules by CTLA-4. In contrast, blocking CD28 on T cells prevents priming but not the induction of tolerance. Therefore, the outcome of antigen recognition by T cells is determined by the interaction of CD28 or CTLA-4 on the T cells with 87 molecules.",
author = "{Perez Quinones}, {Victor L} and {Van Parijs}, Luk and Andre Biuckians and Zheng, {Xin Xiao} and Strom, {Terry B.} and Abbas, {Abul K.}",
year = "1997",
month = "4",
day = "1",
language = "English",
volume = "6",
pages = "411--417",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "4",

}

TY - JOUR

T1 - Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement

AU - Perez Quinones, Victor L

AU - Van Parijs, Luk

AU - Biuckians, Andre

AU - Zheng, Xin Xiao

AU - Strom, Terry B.

AU - Abbas, Abul K.

PY - 1997/4/1

Y1 - 1997/4/1

N2 - Studies of T cell anergy in vitro have led to the widely accepted view that anergy is induced by T cell antigen recognition without costimulation. We show that the induction of T cell anergy in vivo is due to an abortive T cell response that requires recognition of 87 molecules, since blocking 87 maintains T cells in an unactivated but functionally competent state. Furthermore, the induction of anergy is prevented by blocking CTLA-4, the inhibitory T cell receptor for 87 molecules. Thus, in vivo T cell anergy may be induced not because of a lack of costimulation, but as a result of specific recognition of B7 molecules by CTLA-4. In contrast, blocking CD28 on T cells prevents priming but not the induction of tolerance. Therefore, the outcome of antigen recognition by T cells is determined by the interaction of CD28 or CTLA-4 on the T cells with 87 molecules.

AB - Studies of T cell anergy in vitro have led to the widely accepted view that anergy is induced by T cell antigen recognition without costimulation. We show that the induction of T cell anergy in vivo is due to an abortive T cell response that requires recognition of 87 molecules, since blocking 87 maintains T cells in an unactivated but functionally competent state. Furthermore, the induction of anergy is prevented by blocking CTLA-4, the inhibitory T cell receptor for 87 molecules. Thus, in vivo T cell anergy may be induced not because of a lack of costimulation, but as a result of specific recognition of B7 molecules by CTLA-4. In contrast, blocking CD28 on T cells prevents priming but not the induction of tolerance. Therefore, the outcome of antigen recognition by T cells is determined by the interaction of CD28 or CTLA-4 on the T cells with 87 molecules.

UR - http://www.scopus.com/inward/record.url?scp=0030966217&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030966217&partnerID=8YFLogxK

M3 - Article

C2 - 9133420

AN - SCOPUS:0030966217

VL - 6

SP - 411

EP - 417

JO - Immunity

JF - Immunity

SN - 1074-7613

IS - 4

ER -