The ovarian response to stimulation with follicle stimulating hormone/luteinizing hormone releasing hormone (FSH/LH RH) was studied in young, healthy and fertile women with constant iatrogenic anovulation caused by depot medroxyprogesterone acetate or depot chlormadinone acetate injected for contraceptive purposes. Results were compared with those in unstimulated controls. The stimulatory effect of FSH/LH RH manifested itself in mild to moderate signs of estrogenic changes in the vaginal cytology and cervical gland secretion, with a switch from progestational to estrogenic characteristics. Endometrial histology, however, was not modified. It was also apparent that the intramuscular injection of synthetic FSH/LH RH caused definite stimulation in 'resting' ovaries with suppressed ovulation in terms of mitotic and steroidogenic FSH and LH like effects in those women receiving the optimum dosage.
ASJC Scopus subject areas
- Obstetrics and Gynecology