Induction of ovulation with d-trp6-LHRH combined with purified FSH in patients with polycystic ovarian disease

D. Ayalon, M. Ben-David, R. Wohl, R. Jaffe, I. Vagman, N. Eckstein, R. Limor, A. M. Comaru-Schally, A. V. Schally

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Seventeen patients with polycystic ovarian disease (PCOD) and evidence of mild or severe ovarian hyperstimulation syndrome (OHSS) during therapy with CC/hCG, FSH/hCG or hMG/hCG were treated with D-Trp6-LHRH until medical gonadectomy was attained. Under the suppressive therapy with the GnRH agonist (GnRHa) ovulation was induced with FSH/hCG. In 15 out of 17 patients, ovulatory cycles were obtained with this new modality of treatment. Seven patients conceived (3 viable pregnancies and 4 early abortions) after the 1st treatment cycle. Fourteen of the 17 patients demonstrated symptoms of mild OHSS which did not require hospitalization. Only 1 patient developed severe OHSS after the combined treatment. Our results suggest that therapy with GnRHa, especially in its delayed release formulation, is effective for the prevention of severe ovarian hyperstimulation in PCOD patients undergoing treatment with menotropins for the induction of ovulation.

Original languageEnglish (US)
Pages (from-to)319-330
Number of pages12
JournalGynecological Endocrinology
Issue number4
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Obstetrics and Gynecology


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