Induction of neural tissue markers by micronized human spinal cord implants

Ellen M. Carpenter, Carlos Llamas, Billy E. Buck, Theodore I. Malinin

Research output: Contribution to journalArticle

Abstract

The osteoinductive capacity of biological noncellular material has been widely recognized. Studies using bone morphogenetic proteins and acellular bone matrix demonstrate that host mesenchymal cells can be readily transformed into osteoprogenitor cells. The current study sought to determine whether another biological noncellular material, human spinal cord matrix, could induce transformation of host cells into a neural lineage. We demonstrate the formation of neural tissue and the expression of neural-specific lineage markers in host cells colonizing implanted spinal cord fragments and adjacent tissue along with the lack of expression of nonneural lineage markers. These studies demonstrate that the inductive capacity of biological noncellular material is not limited to the osteogenic lineage and suggest that acellular spinal cord matrix could be used to generate host-derived cells for use in neural repair and regeneration.

Original languageEnglish (US)
Pages (from-to)495-503
Number of pages9
JournalJournal of Neuroscience Research
Volume93
Issue number3
DOIs
StatePublished - Mar 1 2015

Keywords

  • Neural differentiation
  • Neural regeneration
  • Spinal cord
  • Xenograft

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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