Induction of mucosal homing virus-specific CD8+ T lymphocytes by attenuated simian immunodeficiency virus

M. A. Cromwell, R. S. Veazey, J. D. Altman, K. G. Mansfield, R. Glickman, T. M. Allen, D. I. Watkins, A. A. Lackner, R. P. Johnson

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50 Scopus citations

Abstract

Induction of virus-specific T-cell responses in mucosal as well as systemic compartments of the immune system is likely to be a critical feature of an effective AIDS vaccine. We investigated whether virus-specific CD8+ lymphocytes induced in rhesus macaques by immunization with attenuated simian immunodeficiency virus (SIV), an approach that is highly effective in eliciting protection against mucosal challenge, express the mucosa-homing receptor α4β7 and traffic to the intestinal mucosa. SIV-specific CD8+ T cells expressing α4β7 were detected in peripheral blood and intestine of macaques infected with attenuated SIV. In contrast, virus-specific T cells in blood of animals immunized cutaneously by a combined DNA-modified vaccinia virus Ankara regimen did not express α4β7. These results demonstrate the selective induction of SIV-specific CD8+ T lymphocytes expressing α4β7 by a vaccine approach that replicates in mucosal tissue and suggest that induction of virus-specific lymphocytes that are able to home to mucosal sites may be an important characteristic of a successful AIDS vaccine.

Original languageEnglish (US)
Pages (from-to)8762-8766
Number of pages5
JournalJournal of virology
Volume74
Issue number18
DOIs
StatePublished - Sep 13 2000

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ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Cromwell, M. A., Veazey, R. S., Altman, J. D., Mansfield, K. G., Glickman, R., Allen, T. M., Watkins, D. I., Lackner, A. A., & Johnson, R. P. (2000). Induction of mucosal homing virus-specific CD8+ T lymphocytes by attenuated simian immunodeficiency virus. Journal of virology, 74(18), 8762-8766. https://doi.org/10.1128/JVI.74.18.8762-8766.2000