Abstract
Induction of virus-specific T-cell responses in mucosal as well as systemic compartments of the immune system is likely to be a critical feature of an effective AIDS vaccine. We investigated whether virus-specific CD8+ lymphocytes induced in rhesus macaques by immunization with attenuated simian immunodeficiency virus (SIV), an approach that is highly effective in eliciting protection against mucosal challenge, express the mucosa-homing receptor α4β7 and traffic to the intestinal mucosa. SIV-specific CD8+ T cells expressing α4β7 were detected in peripheral blood and intestine of macaques infected with attenuated SIV. In contrast, virus-specific T cells in blood of animals immunized cutaneously by a combined DNA-modified vaccinia virus Ankara regimen did not express α4β7. These results demonstrate the selective induction of SIV-specific CD8+ T lymphocytes expressing α4β7 by a vaccine approach that replicates in mucosal tissue and suggest that induction of virus-specific lymphocytes that are able to home to mucosal sites may be an important characteristic of a successful AIDS vaccine.
| Original language | English |
|---|---|
| Pages (from-to) | 8762-8766 |
| Number of pages | 5 |
| Journal | Journal of Virology |
| Volume | 74 |
| Issue number | 18 |
| DOIs | |
| State | Published - Sep 13 2000 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
Cite this
Induction of mucosal homing virus-specific CD8+ T lymphocytes by attenuated simian immunodeficiency virus. / Cromwell, M. A.; Veazey, R. S.; Altman, J. D.; Mansfield, K. G.; Glickman, R.; Allen, T. M.; Watkins, David; Lackner, A. A.; Johnson, R. P.
In: Journal of Virology, Vol. 74, No. 18, 13.09.2000, p. 8762-8766.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Induction of mucosal homing virus-specific CD8+ T lymphocytes by attenuated simian immunodeficiency virus
AU - Cromwell, M. A.
AU - Veazey, R. S.
AU - Altman, J. D.
AU - Mansfield, K. G.
AU - Glickman, R.
AU - Allen, T. M.
AU - Watkins, David
AU - Lackner, A. A.
AU - Johnson, R. P.
PY - 2000/9/13
Y1 - 2000/9/13
N2 - Induction of virus-specific T-cell responses in mucosal as well as systemic compartments of the immune system is likely to be a critical feature of an effective AIDS vaccine. We investigated whether virus-specific CD8+ lymphocytes induced in rhesus macaques by immunization with attenuated simian immunodeficiency virus (SIV), an approach that is highly effective in eliciting protection against mucosal challenge, express the mucosa-homing receptor α4β7 and traffic to the intestinal mucosa. SIV-specific CD8+ T cells expressing α4β7 were detected in peripheral blood and intestine of macaques infected with attenuated SIV. In contrast, virus-specific T cells in blood of animals immunized cutaneously by a combined DNA-modified vaccinia virus Ankara regimen did not express α4β7. These results demonstrate the selective induction of SIV-specific CD8+ T lymphocytes expressing α4β7 by a vaccine approach that replicates in mucosal tissue and suggest that induction of virus-specific lymphocytes that are able to home to mucosal sites may be an important characteristic of a successful AIDS vaccine.
AB - Induction of virus-specific T-cell responses in mucosal as well as systemic compartments of the immune system is likely to be a critical feature of an effective AIDS vaccine. We investigated whether virus-specific CD8+ lymphocytes induced in rhesus macaques by immunization with attenuated simian immunodeficiency virus (SIV), an approach that is highly effective in eliciting protection against mucosal challenge, express the mucosa-homing receptor α4β7 and traffic to the intestinal mucosa. SIV-specific CD8+ T cells expressing α4β7 were detected in peripheral blood and intestine of macaques infected with attenuated SIV. In contrast, virus-specific T cells in blood of animals immunized cutaneously by a combined DNA-modified vaccinia virus Ankara regimen did not express α4β7. These results demonstrate the selective induction of SIV-specific CD8+ T lymphocytes expressing α4β7 by a vaccine approach that replicates in mucosal tissue and suggest that induction of virus-specific lymphocytes that are able to home to mucosal sites may be an important characteristic of a successful AIDS vaccine.
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UR - http://www.scopus.com/inward/citedby.url?scp=0033864867&partnerID=8YFLogxK
U2 - 10.1128/JVI.74.18.8762-8766.2000
DO - 10.1128/JVI.74.18.8762-8766.2000
M3 - Article
C2 - 10954580
AN - SCOPUS:0033864867
VL - 74
SP - 8762
EP - 8766
JO - Journal of Virology
JF - Journal of Virology
SN - 0022-538X
IS - 18
ER -