Induction of localized cochlear hypothermia

Lee P. Smith, Adrien Eshraghi, Douglas E. Whitley, Thomas R Van De Water, Thomas J. Balkany

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Conclusions. Localized cochlear hypothermia was induced in a rat model, demonstrating the feasibility of modulating cochlear temperature without affecting core body temperature. Objectives. Systemic hypothermia has been demonstrated to protect the rat cochlea against electrode insertion trauma-induced hearing loss. Due to potential adverse effects of systemic hypothermia, we set out to demonstrate the feasibility of inducing localized cochlear hypothermia and compared the efficacy of three cooling techniques. Materials and methods. Twenty-four ears were prepared by sealing a temperature micro-probe into the basal turn of the cochlea. Cochleae were then cooled by cold saline irrigation of the external auditory canal (EAC) or bulla or by direct application of ice over the bulla. Cochlear temperature measurements were recorded every 30 s during the cooling period until stable. Rectal temperature was monitored continuously and maintained at 36°C. Results. All techniques resulted in cochlear hypothermia without a concomitant change in rectal temperature. EAC irrigation (14°C and 11°C) decreased cochlear temperature on average by 1.1°C and 1.6°C, respectively. Bulla irrigation (14°C and 11°C) decreased cochlear temperature on average by 3.3°C and 4.1°C, respectively. The ice produced an average cochlear temperature decrease of 4.1°C. In all cases, a cochlear temperature nadir was reached in 5-6 min with no significant differences between groups with respect to time.

Original languageEnglish
Pages (from-to)228-233
Number of pages6
JournalActa Oto-Laryngologica
Volume127
Issue number3
DOIs
StatePublished - Feb 28 2007

Fingerprint

Cochlea
Hypothermia
Temperature
Blister
Ear Canal
Ice
Induced Hypothermia
Body Temperature
Hearing Loss
Ear
Electrodes

Keywords

  • Cochlear cooling
  • Cochlear implantation
  • Hearing loss
  • Localized hypothermia
  • Otoprotection
  • Systemic hypothermia

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Smith, L. P., Eshraghi, A., Whitley, D. E., Van De Water, T. R., & Balkany, T. J. (2007). Induction of localized cochlear hypothermia. Acta Oto-Laryngologica, 127(3), 228-233. https://doi.org/10.1080/00016480600794487

Induction of localized cochlear hypothermia. / Smith, Lee P.; Eshraghi, Adrien; Whitley, Douglas E.; Van De Water, Thomas R; Balkany, Thomas J.

In: Acta Oto-Laryngologica, Vol. 127, No. 3, 28.02.2007, p. 228-233.

Research output: Contribution to journalArticle

Smith, LP, Eshraghi, A, Whitley, DE, Van De Water, TR & Balkany, TJ 2007, 'Induction of localized cochlear hypothermia', Acta Oto-Laryngologica, vol. 127, no. 3, pp. 228-233. https://doi.org/10.1080/00016480600794487
Smith LP, Eshraghi A, Whitley DE, Van De Water TR, Balkany TJ. Induction of localized cochlear hypothermia. Acta Oto-Laryngologica. 2007 Feb 28;127(3):228-233. https://doi.org/10.1080/00016480600794487
Smith, Lee P. ; Eshraghi, Adrien ; Whitley, Douglas E. ; Van De Water, Thomas R ; Balkany, Thomas J. / Induction of localized cochlear hypothermia. In: Acta Oto-Laryngologica. 2007 ; Vol. 127, No. 3. pp. 228-233.
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