Induction of chronic neurologic disease in mice with canine distemper virus

M. J. Lyons, W. W. Hall, Carol Petito, V. Cam, J. B. Zabriskie

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The capacity of a mouse-adapted strain of canine distemper virus (CDV) to induce central nervous system (CNS) disease in weanling mice was investigated. Lethality of infection was found to be mouse-strain-dependent. In sensitive strains, an acute meningoencephalomyelitis developed. Brain tissue from acutely ill animals demonstrated numerous foci of viral antigen, and extracts yielded infectious virus. Mice of resistant strains, notably the SJL strain, survived the effect of acute infection, appeared well for several weeks, and then began to develop signs of subacute CNS disease. Preliminary histopathologic examination of brain and cord from acutely ill animals revealed prominent perivascular mononuclear cell infiltrates, mononuclear cell meningitis, and gliosis. These features were also found in the subacute disease, where, however, the lesions were less severy. Also, in the latter, virus antigen could not be demonstrated. The results indicate that CDV infection of mice may provide a promising model system for the study of virus-induced chronic CNS disease.

Original languageEnglish (US)
Pages (from-to)92-98
Number of pages7
JournalNeurology
Volume30
Issue number7 II
StatePublished - Oct 10 1980
Externally publishedYes

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Canine Distemper Virus
Nervous System Diseases
Chronic Disease
Central Nervous System Diseases
Viruses
Gliosis
Viral Antigens
Brain
Virus Diseases
Infection
Meningitis
Antigens

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Lyons, M. J., Hall, W. W., Petito, C., Cam, V., & Zabriskie, J. B. (1980). Induction of chronic neurologic disease in mice with canine distemper virus. Neurology, 30(7 II), 92-98.

Induction of chronic neurologic disease in mice with canine distemper virus. / Lyons, M. J.; Hall, W. W.; Petito, Carol; Cam, V.; Zabriskie, J. B.

In: Neurology, Vol. 30, No. 7 II, 10.10.1980, p. 92-98.

Research output: Contribution to journalArticle

Lyons, MJ, Hall, WW, Petito, C, Cam, V & Zabriskie, JB 1980, 'Induction of chronic neurologic disease in mice with canine distemper virus', Neurology, vol. 30, no. 7 II, pp. 92-98.
Lyons MJ, Hall WW, Petito C, Cam V, Zabriskie JB. Induction of chronic neurologic disease in mice with canine distemper virus. Neurology. 1980 Oct 10;30(7 II):92-98.
Lyons, M. J. ; Hall, W. W. ; Petito, Carol ; Cam, V. ; Zabriskie, J. B. / Induction of chronic neurologic disease in mice with canine distemper virus. In: Neurology. 1980 ; Vol. 30, No. 7 II. pp. 92-98.
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