Induction of AIDS-like disease in macaque monkeys with T-cell tropic retrovirus STLV-III

N. L. Letvin, M. D. Daniel, P. K. Sehgal, R. C. Desrosiers, R. D. Hunt, L. M. Waldron, J. J. Mackey, D. K. Schmidt, L. V. Chalifoux, N. W. King

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Abstract

The T-cell tropic retrovirus of macaque monkeys STLV-III has morphologic, growth, and antigenic properties indicating that it is related to HTLV-III/LAV, the etiologic agent of the acquired immune deficiency syndrome (AIDS) in humans. Four of six rhesus monkeys died within 160 days of STLV-III inoculation with a wasting syndrome, opportunistic infections, a primary retroviral encephalitis, and immunologic abnormalities including a decrease in T4+ peripheral blood lymphocytes. These data show that an immunodeficiency syndrome can be produced experimentally in a nonhuman primate by an agent from the HTLV-III/LAV group of retroviruses. The STLV-III-macaque system will thus provide a useful model for the study of antiviral agents and vaccine development for human AIDS.

Original languageEnglish (US)
Pages (from-to)71-73
Number of pages3
JournalScience
Volume230
Issue number4721
DOIs
StatePublished - 1985

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    Letvin, N. L., Daniel, M. D., Sehgal, P. K., Desrosiers, R. C., Hunt, R. D., Waldron, L. M., Mackey, J. J., Schmidt, D. K., Chalifoux, L. V., & King, N. W. (1985). Induction of AIDS-like disease in macaque monkeys with T-cell tropic retrovirus STLV-III. Science, 230(4721), 71-73. https://doi.org/10.1126/science.2412295