Induction of AIDS in rhesus monkeys by molecularly cloned simian immunodeficiency virus

Harry Kestler; Toshiaki Kodama; Douglas Ringler; Marta Marthas; Niels Pedersen; Andrew Lackner; Dean Regier; Prabhat Sehgal; Muthiah Daniel; Norval King; Ronald Desrosiers

doi:10.1126/science.2160735

Induction of AIDS in rhesus monkeys by molecularly cloned simian immunodeficiency virus

Harry Kestler, Toshiaki Kodama, Douglas Ringler, Marta Marthas, Niels Pedersen, Andrew Lackner, Dean Regier, Prabhat Sehgal, Muthiah Daniel, Norval King, Ronald Desrosiers

Research output: Contribution to journal › Article › peer-review

472 Scopus citations

Abstract

Better understanding of the pathogenesis of acquired immunodeficiency syndrome (AIDS) would be greatly facilitated by a relevant animal model that uses molecularly cloned virus of defined sequence to induce the disease. Such a system would also be of great value for AIDS vaccine research. An infectious molecular clone of simian immunodeficiency virus (SIV) was identified that induces AIDS in common rhesus monkeys in a time frame suitable for laboratory investigation. These results provide another strong link in the chain of evidence for the viral etiology of AIDS. More importantly, they define a system for molecular dissection of the determinants of AIDS pathogenesis.

Original language	English (US)
Pages (from-to)	1109-1112
Number of pages	4
Journal	Science
Volume	248
Issue number	4959
DOIs	https://doi.org/10.1126/science.2160735
State	Published - 1990
Externally published	Yes

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Induction of AIDS in rhesus monkeys by molecularly cloned simian immunodeficiency virus. / Kestler, Harry; Kodama, Toshiaki; Ringler, Douglas; Marthas, Marta; Pedersen, Niels; Lackner, Andrew; Regier, Dean; Sehgal, Prabhat; Daniel, Muthiah; King, Norval; Desrosiers, Ronald.

In: Science, Vol. 248, No. 4959, 1990, p. 1109-1112.

Research output: Contribution to journal › Article › peer-review

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abstract = "Better understanding of the pathogenesis of acquired immunodeficiency syndrome (AIDS) would be greatly facilitated by a relevant animal model that uses molecularly cloned virus of defined sequence to induce the disease. Such a system would also be of great value for AIDS vaccine research. An infectious molecular clone of simian immunodeficiency virus (SIV) was identified that induces AIDS in common rhesus monkeys in a time frame suitable for laboratory investigation. These results provide another strong link in the chain of evidence for the viral etiology of AIDS. More importantly, they define a system for molecular dissection of the determinants of AIDS pathogenesis.",

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AU - Lackner, Andrew

AU - Regier, Dean

AU - Sehgal, Prabhat

AU - Daniel, Muthiah

AU - King, Norval

AU - Desrosiers, Ronald

PY - 1990

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Induction of AIDS in rhesus monkeys by molecularly cloned simian immunodeficiency virus

Abstract

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