Induction of AIDS in rhesus monkeys by molecularly cloned simian immunodeficiency virus

Harry Kestler, Toshiaki Kodama, Douglas Ringler, Marta Marthas, Niels Pedersen, Andrew Lackner, Dean Regier, Prabhat Sehgal, Muthiah Daniel, Norval King, Ronald Desrosiers

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459 Scopus citations

Abstract

Better understanding of the pathogenesis of acquired immunodeficiency syndrome (AIDS) would be greatly facilitated by a relevant animal model that uses molecularly cloned virus of defined sequence to induce the disease. Such a system would also be of great value for AIDS vaccine research. An infectious molecular clone of simian immunodeficiency virus (SIV) was identified that induces AIDS in common rhesus monkeys in a time frame suitable for laboratory investigation. These results provide another strong link in the chain of evidence for the viral etiology of AIDS. More importantly, they define a system for molecular dissection of the determinants of AIDS pathogenesis.

Original languageEnglish (US)
Pages (from-to)1109-1112
Number of pages4
JournalScience
Volume248
Issue number4959
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

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    Kestler, H., Kodama, T., Ringler, D., Marthas, M., Pedersen, N., Lackner, A., Regier, D., Sehgal, P., Daniel, M., King, N., & Desrosiers, R. (1990). Induction of AIDS in rhesus monkeys by molecularly cloned simian immunodeficiency virus. Science, 248(4959), 1109-1112. https://doi.org/10.1126/science.2160735