Induction and subsequent rupture of aneurysms of the circle of Willis after radiation therapy in Ehlers-Danlos syndrome: A plausible hypothesis

Andrei I. Holodny, Michael Deck, Carol K. Petito

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Multiple aneurysms of the circle of Willis developed in a 62-year-old woman with Ehlers-Danlos syndrome (EDS) within 7 months of initiation of radiation therapy to the brain. A major response of the arterial wall to radiation damage is the formation of collagen. In patients with EDS, in whom there is a defect in collagen, this repair is incomplete. We propose that the incomplete repair of the arterial wall consequent to EDS resulted in weakness of these walls, formation of an aneurysm, and, ultimately, fatal subarachnoid hemorrhage.

Original languageEnglish (US)
Pages (from-to)226-232
Number of pages7
JournalAmerican Journal of Neuroradiology
Volume17
Issue number2
StatePublished - Mar 8 1996

Keywords

  • Aneurysm, cerebral
  • Ehlers-Danlos syndrome
  • Iatrogenic disease or disorder
  • Therapeutic radiology, complications

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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