Induced pluripotent stem cells in tissue engineering and regenerative medicine

Harjit Singh, Derek M. Dykxhoorn

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Recent advances in stem cell biology have transformed our understanding of regenerative medicine and tissue engineering. The ability of stem cells to self-renew and differentiate into cell types representative of the three embryonic germ layers have made these cells attractive tools for cell and tissue-based therapies. Induced pluripotent stem cells (iPSCs) development from somatic cells bypasses the need for embryonic stem cells (ESCs) providing a source of autologous, patient-specific stem cells for personalized cell-based therapies. To that end, novel tissue engineering approaches are needed to move iPSC-based technologies from the laboratory into the clinic.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Tissue Engineering and Regenerative Medicine
PublisherElsevier
Pages57-64
Number of pages8
Volume1-3
ISBN (Electronic)9780128136997
ISBN (Print)9780128137000
DOIs
StatePublished - Jan 1 2019
Externally publishedYes

Keywords

  • Cell-specific reporter construct
  • Directed differentiation
  • Genome editing
  • Induced pluripotent stem cells
  • Precision medicine
  • Regenerative medicine
  • Stem cell-based therapy
  • Tissue engineering
  • Tissue organoids
  • Transplantation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Singh, H., & Dykxhoorn, D. M. (2019). Induced pluripotent stem cells in tissue engineering and regenerative medicine. In Encyclopedia of Tissue Engineering and Regenerative Medicine (Vol. 1-3, pp. 57-64). Elsevier. https://doi.org/10.1016/B978-0-12-801238-3.65742-2