Induced pluripotent stem cells and promises of neuroregenerative medicine

Ashok Verma, Nipun Verma

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

First created in 2006 from adult somatic cells by a simple molecular genetic trick, induced pluripotent stem cells (iPS) system is the latest platform in stem cell research. Induced pluripotent stem cells are produced by nuclear reprogramming technology and they resemble embryonic stem cells (ES) in key elements; they possess the potentiality to differentiate into any type of cell in the body. More importantly, the iPS platform has distinct advantage over ES system in the sense that iPS-derived cells are autologous and therefore the iPS-derived transplantation does not require immunosuppressive therapy. In addition, iPS research obviates the political and ethical quandary associated with embryo destruction and ES research. This remarkable discovery of cellular plasticity has important medical implications. This brief review summarizes currently available stem cell platforms, with emphasis on cellular reprogramming and iPS technology and its application in disease modeling and cell replacement therapy in neurodegenerative diseases.

Original languageEnglish (US)
Pages (from-to)555-557
Number of pages3
JournalNeurology India
Volume59
Issue number4
DOIs
StatePublished - Jul 1 2011

Keywords

  • Cell therapy
  • embryonic stem cell
  • induced stem cell
  • multipotent
  • pluripotent

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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