Indolent peripheral T-cell lymphoma involving the gastrointestinal tract

Vasiliki Leventaki, John T. Manning, Rajayalakshmi Luthra, Pramod Mehta, Yasuhiro Oki, Jorge E. Romaguera, L. Jeffrey Medeiros, Francisco Vega

Research output: Contribution to journalArticle

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Abstract

We describe an unusual case of indolent peripheral T-cell lymphoma with multifocal involvement of the gastrointestinal tract. The patient, a 42-year-old Asian man, has been followed up for more than 10 years without chemotherapy and multiple gastrointestinal biopsies showing similar findings. Histologically, the neoplasm expanded into the lamina propria and/or focally extended into the submucosa and was composed of small- to medium-sized lymphocytes with slightly irregular nuclear contours and clear cytoplasm and rare large lymphocytes. The tumor cells were positive for CD3, CD8, granzyme B, and TIA-1 (subset) and negative for CD5, CD56, and Epstein-Barr virus-encoded RNA. Molecular studies for T-cell receptor γ and/or β chain gene rearrangement demonstrated the same clone at different sites and times during the course of the disease. Rare cases of indolent peripheral T-cell lymphoma of the gastrointestinal tract have been previously described and need to be further characterized to avoid the use of aggressive chemotherapy.

Original languageEnglish
Pages (from-to)421-426
Number of pages6
JournalHuman Pathology
Volume45
Issue number2
DOIs
StatePublished - Feb 1 2014

Fingerprint

Peripheral T-Cell Lymphoma
Gastrointestinal Tract
Lymphocytes
Drug Therapy
Granzymes
Gene Rearrangement
T-Cell Antigen Receptor
Human Herpesvirus 4
Neoplasms
Cytoplasm
Mucous Membrane
Clone Cells
RNA
Biopsy

Keywords

  • Gastrointestinal tract
  • Indolent lymphoma
  • NK-cell enteropathy
  • T-cell lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Leventaki, V., Manning, J. T., Luthra, R., Mehta, P., Oki, Y., Romaguera, J. E., ... Vega, F. (2014). Indolent peripheral T-cell lymphoma involving the gastrointestinal tract. Human Pathology, 45(2), 421-426. https://doi.org/10.1016/j.humpath.2013.08.003

Indolent peripheral T-cell lymphoma involving the gastrointestinal tract. / Leventaki, Vasiliki; Manning, John T.; Luthra, Rajayalakshmi; Mehta, Pramod; Oki, Yasuhiro; Romaguera, Jorge E.; Medeiros, L. Jeffrey; Vega, Francisco.

In: Human Pathology, Vol. 45, No. 2, 01.02.2014, p. 421-426.

Research output: Contribution to journalArticle

Leventaki, V, Manning, JT, Luthra, R, Mehta, P, Oki, Y, Romaguera, JE, Medeiros, LJ & Vega, F 2014, 'Indolent peripheral T-cell lymphoma involving the gastrointestinal tract', Human Pathology, vol. 45, no. 2, pp. 421-426. https://doi.org/10.1016/j.humpath.2013.08.003
Leventaki V, Manning JT, Luthra R, Mehta P, Oki Y, Romaguera JE et al. Indolent peripheral T-cell lymphoma involving the gastrointestinal tract. Human Pathology. 2014 Feb 1;45(2):421-426. https://doi.org/10.1016/j.humpath.2013.08.003
Leventaki, Vasiliki ; Manning, John T. ; Luthra, Rajayalakshmi ; Mehta, Pramod ; Oki, Yasuhiro ; Romaguera, Jorge E. ; Medeiros, L. Jeffrey ; Vega, Francisco. / Indolent peripheral T-cell lymphoma involving the gastrointestinal tract. In: Human Pathology. 2014 ; Vol. 45, No. 2. pp. 421-426.
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