Indolent peripheral T-cell lymphoma involving the gastrointestinal tract

Vasiliki Leventaki, John T. Manning, Rajayalakshmi Luthra, Pramod Mehta, Yasuhiro Oki, Jorge E. Romaguera, L. Jeffrey Medeiros, Francisco Vega

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


We describe an unusual case of indolent peripheral T-cell lymphoma with multifocal involvement of the gastrointestinal tract. The patient, a 42-year-old Asian man, has been followed up for more than 10 years without chemotherapy and multiple gastrointestinal biopsies showing similar findings. Histologically, the neoplasm expanded into the lamina propria and/or focally extended into the submucosa and was composed of small- to medium-sized lymphocytes with slightly irregular nuclear contours and clear cytoplasm and rare large lymphocytes. The tumor cells were positive for CD3, CD8, granzyme B, and TIA-1 (subset) and negative for CD5, CD56, and Epstein-Barr virus-encoded RNA. Molecular studies for T-cell receptor γ and/or β chain gene rearrangement demonstrated the same clone at different sites and times during the course of the disease. Rare cases of indolent peripheral T-cell lymphoma of the gastrointestinal tract have been previously described and need to be further characterized to avoid the use of aggressive chemotherapy.

Original languageEnglish (US)
Pages (from-to)421-426
Number of pages6
JournalHuman pathology
Issue number2
StatePublished - Feb 2014


  • Gastrointestinal tract
  • Indolent lymphoma
  • NK-cell enteropathy
  • T-cell lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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