Individual histone deacetylases in Drosophila modulate transcription of distinct genes

Younsook Cho, Anthony Griswold, Catherine Campbell, Kyung Tai Min

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


Lysine residues on the N-terminal tails of histones in chromatin are the primary targets of histone acetyltransferases (HATs) and histone deacetylases (HDACs) in eukaryotes. Regulation of histone acetylation by these two classes of enzymes plays significant roles in controlling transcriptional activity in cells. Eukaryotic organisms have several different HDACs, but the biological roles of each HDAC are still not clear. To understand the physiological functions of HDACs, we characterized six different Drosophila HDACs, including Rpd3, HDAC3, HDAC4, HDAC6-S, HDAC6-L, and Sir2, by developmental expression pattern, transcriptional profiles of target genes, and sensitivity to HDAC inhibitors. We found that each HDAC has a distinct temporal expression pattern and regulates transcription of a unique set of genes. Furthermore, we demonstrated differential sensitivity of HDACs to inhibitors. These results show that each individual HDAC plays different roles in regulating genes involved in various biological processes.

Original languageEnglish (US)
Pages (from-to)606-617
Number of pages12
Issue number5
StatePublished - Nov 2005
Externally publishedYes


  • Aging
  • Drosophila
  • HDAC inhibitors
  • HDACs
  • Microarray

ASJC Scopus subject areas

  • Genetics


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