Individual histone deacetylases in Drosophila modulate transcription of distinct genes

Younsook Cho, Anthony Griswold, Catherine Campbell, Kyung Tai Min

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Lysine residues on the N-terminal tails of histones in chromatin are the primary targets of histone acetyltransferases (HATs) and histone deacetylases (HDACs) in eukaryotes. Regulation of histone acetylation by these two classes of enzymes plays significant roles in controlling transcriptional activity in cells. Eukaryotic organisms have several different HDACs, but the biological roles of each HDAC are still not clear. To understand the physiological functions of HDACs, we characterized six different Drosophila HDACs, including Rpd3, HDAC3, HDAC4, HDAC6-S, HDAC6-L, and Sir2, by developmental expression pattern, transcriptional profiles of target genes, and sensitivity to HDAC inhibitors. We found that each HDAC has a distinct temporal expression pattern and regulates transcription of a unique set of genes. Furthermore, we demonstrated differential sensitivity of HDACs to inhibitors. These results show that each individual HDAC plays different roles in regulating genes involved in various biological processes.

Original languageEnglish (US)
Pages (from-to)606-617
Number of pages12
JournalGenomics
Volume86
Issue number5
DOIs
StatePublished - Nov 1 2005
Externally publishedYes

Fingerprint

Histone Deacetylases
Drosophila
Genes
Histones
Biological Phenomena
Histone Acetyltransferases
Acetylation
Eukaryota
Lysine
Chromatin
Tail

Keywords

  • Aging
  • Drosophila
  • HDAC inhibitors
  • HDACs
  • Microarray

ASJC Scopus subject areas

  • Genetics

Cite this

Individual histone deacetylases in Drosophila modulate transcription of distinct genes. / Cho, Younsook; Griswold, Anthony; Campbell, Catherine; Min, Kyung Tai.

In: Genomics, Vol. 86, No. 5, 01.11.2005, p. 606-617.

Research output: Contribution to journalArticle

Cho, Younsook ; Griswold, Anthony ; Campbell, Catherine ; Min, Kyung Tai. / Individual histone deacetylases in Drosophila modulate transcription of distinct genes. In: Genomics. 2005 ; Vol. 86, No. 5. pp. 606-617.
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