Individual cognitive and depressive traits associated with maternal versus paternal family history of Late-onset Alzheimer's disease: Proactive semantic interference versus standard neuropsychological assessments

Kathleen E. Wilson, Carolina Abulafia, David A. Loewenstein, Daniel E. Vigo, Gustavo Sevlever, Charles B. Nemeroff, Mirta F. Villarreal, Salvador M. Guinjoan

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The main objective of this study was to assess cognitive and depressive manifestations associated with Alzheimer's disease in middle-aged asymptomatic individuals with maternal versus paternal family history of the disease using standardly used neuropsychological measures and a novel cognitive stress test, the Loewenstein-Acevedo Scale for Semantic Interference and Learning (LASSI-L). We evaluated cognitive abilities in offspring of late-onset Alzheimer's disease patients and a control group with no family history of dementia. Results showed lower cognitive performance in verbal episodic memory and semantic memory in participants with an Alzheimer's parent, especially in individuals with a maternal family history of the disease. While the standardly used neuropsychological evaluations were sensitive to differences in cognition between those with a maternal history of the disease and the control group, the LASSI-L was sensitive to proactive semantic interference impairments in both groups with a paternal and maternal family history of the disease. Depressive symptoms may affect cognitive performance differently in individuals with a family history of Alzheimer's disease compared to a control group, especially in individuals with a maternal history of the disease. This study highlights the value of semantic interference paradigms in early detection of Alzheimer's and emphasizes the importance of studying maternal versus paternal transmission of the disease.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalPersonalized Medicine in Psychiatry
Volume11-12
DOIs
StatePublished - Nov 1 2018

Keywords

  • Early diagnosis
  • Late-onset Alzheimer's disease
  • Loewenstein-Acevedo Scale for Semantic Interference and Learning (LASSI-L)
  • Rey Auditory Visual Learning Test (RAVLT)

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Neurology
  • Clinical Psychology

Fingerprint

Dive into the research topics of 'Individual cognitive and depressive traits associated with maternal versus paternal family history of Late-onset Alzheimer's disease: Proactive semantic interference versus standard neuropsychological assessments'. Together they form a unique fingerprint.

Cite this