Indispensable Role of Ion Channels and Transporters in the Auditory System

Rahul Mittal, Mayank Aranke, Luca H. Debs, Desiree Nguyen, Amit P. Patel, M'hamed Grati, Jeenu Mittal, Denise Yan, Prem Chapagain, Adrien Eshraghi, Xue Z Liu

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Ear is a complex system where appropriate ionic composition is essential for maintaining the tissue homeostasis and hearing function. Ion transporters and channels present in the auditory system plays a crucial role in maintaining proper ionic composition in the ear. The extracellular fluid, called endolymph, found in the cochlea of the mammalian inner ear is particularly unique due to its electrochemical properties. At an endocochlear potential of about +80mV, signaling initiated by acoustic stimuli at the level of the hair cells is dependent on the unusually high potassium (K+) concentration of endolymph. There are ion channels and transporters that exists in the ear to ensure that K+ is continually being cycled into the stria media endolymph. This review is focused on the discussion of the molecular and genetic basis of previously and newly recognized ion channels and transporters that support sensory hair cell excitation based on recent knock-in and knock-out studies of these channels. This article also addresses the molecular and genetic defects and the pathophysiology behind Meniere's disease as well as how the dysregulation of these ion transporters can result in severe defects in hearing or even deafness. Understanding the role of ion channels and transporters in the auditory system will facilitate in designing effective treatment modalities against ear disorders including Meniere's disease and hearing loss.

Original languageEnglish (US)
JournalJournal of Cellular Physiology
DOIs
StateAccepted/In press - 2016

Fingerprint

Audition
Endolymph
Ion Channels
Ear
Meniere Disease
Tissue homeostasis
Cells
Ions
Hearing
Molecular Biology
Defects
Chemical analysis
Electrochemical properties
Large scale systems
Cochlea
Extracellular Fluid
Potassium
Deafness
Inner Ear
Acoustics

ASJC Scopus subject areas

  • Medicine(all)
  • Physiology
  • Clinical Biochemistry
  • Cell Biology

Cite this

Indispensable Role of Ion Channels and Transporters in the Auditory System. / Mittal, Rahul; Aranke, Mayank; Debs, Luca H.; Nguyen, Desiree; Patel, Amit P.; Grati, M'hamed; Mittal, Jeenu; Yan, Denise; Chapagain, Prem; Eshraghi, Adrien; Liu, Xue Z.

In: Journal of Cellular Physiology, 2016.

Research output: Contribution to journalArticle

Mittal, Rahul ; Aranke, Mayank ; Debs, Luca H. ; Nguyen, Desiree ; Patel, Amit P. ; Grati, M'hamed ; Mittal, Jeenu ; Yan, Denise ; Chapagain, Prem ; Eshraghi, Adrien ; Liu, Xue Z. / Indispensable Role of Ion Channels and Transporters in the Auditory System. In: Journal of Cellular Physiology. 2016.
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