Independent control of mucosal and total airway blood flow during hypoxemia

S. Elsasser, W. M. Long, Horst J. Baier, A. D. Chediak, A. Wanner

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

In the larger airways, the blood circulation forms a subepithelial (mucosal) and outer (peribronchial) microvascular network. This raises the possibility that blood flow in these two networks is regulated independently. We used hypoxemia as a stimulus to induce changes in tracheal mucosal blood flow normalized for systemic arterial pressure (Q̇(tr n)) measured with an inert soluble gas technique and total bronchial blood flow (Q̇(br)) and normalized Q̇(br)(Q̇(brn)) measured with an electromagnetic flow probe in anesthetized sheep. Fifteen minutes of hypoxemia [PO2 40 ± 7 (SD) Torr] decreased mean Q̇(tr n) from 1.1 ± 0.4 to 0.8 ± 0.4 ml · min-1 · mmHg-1 · 102 (-27%; P < 0.05; n = 7) and increased mean Q̇(br n) from 12.1 ± 3.2 to 17.1 ± 5.4 ml · min-1 · mmHg-1 · 102 (+41%; P < 0.05; n = 6). The rise in Q̇(br) correlated with cardiac output (r = 0.68; P < 0.05). Phentolamine pretreatment (0.1 mg/kg iv) blunted the hypoxemia-related decrease of mean Q̇(tr n) (-8%; P = NS). Tyramine (2.5 mg) applied locally to the trachea decreased mean Q̇(tr n) significantly after 30 and 45 min by 31 and 19%, respectively (P < 0.05). 6-Hydroxydopamine (0.2 mg 4 times for 1 h locally applied) prevented the hypoxemia-induced as well as local tyramine-induced decrease in mean Q̇(tr n) (0 and 0%). We conclude that, during arterial hypoxemia, 1) an increase in total airway blood flow is associated with a decrease in airway mucosal blood flow, 2) total airway blood flow correlates with cardiac output, and 3) the decrease in Q̇(tr n) is at least partly mediated by local catecholamine release. These findings suggest an independent adrenergic regulation of airway mucosal blood flow.

Original languageEnglish (US)
Pages (from-to)223-228
Number of pages6
JournalJournal of applied physiology
Volume71
Issue number1
DOIs
StatePublished - Jan 1 1991

Keywords

  • adrenergic nervous system
  • bronchial circulation
  • microcirculation
  • vasoconstriction

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Fingerprint Dive into the research topics of 'Independent control of mucosal and total airway blood flow during hypoxemia'. Together they form a unique fingerprint.

  • Cite this